2010 Fiscal Year Final Research Report
Construction of drug delivery systems involving metastasis
| Project/Area Number |
21700491
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
KOJIMA Chie Osaka Prefecture University, 21世紀科学研究機構, 講師 (50405346)
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| Co-Investigator(Renkei-kenkyūsha) |
INUI Takashi 大阪府立大学, 生命環境科学研究科, 教授 (80352912)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 薬物輸送 / ゲル / ナノ医療 / 高分子材料 / 乳癌 |
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| Research Abstract |
We have studied drug delivery system involving metastasis for cancer therapy. Collagen gels containing drug-conjugated dendrimer exhibited the selective drug action against highly metastatic breast tumor cells. In this study, drug-conjugated poly(glutamic acid) enhanced the selectivity in metastasis, and modification of collagen peptide was influenced on the drug action. Collagen peptide-modified dendrimer with anticancer drugs via hydrazone bond showed the antitumor growth activity. Therefore, this kind of material is useful for a novel type of drug delivery system.
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