2010 Fiscal Year Final Research Report
Identification of biomarker for the combination therapy with IFN and ribavirin by the mass spectrometry
| Project/Area Number |
21700507
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical systems
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| Research Institution | Kobe University |
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Principal Investigator |
YANO Yoshihiko Kobe University, 大学院・医学研究科, 講師 (60419489)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 検査 / 診断システム |
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| Research Abstract |
Hepatitis virus C is an oncogenic virus to induce liver cirrhosis and hepatocellular carcinoma via chronic inflammation. Pegylated-inferferon (PEG-IFN) and ribavirin (RBV) combination therapy is an established therapy, but its efficacy is still low. Based on this background, identification of unknown biomarkers in relation to therapeutic efficacy was carried out by using of the mass spectrometry. This research would be helpful to develop a future therapy.
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[Journal Article] Activation of Aryl Hydrocarbon Receptor Induces Hepatic Steatosis via Upregulation of Fatty Acid Transport.2010
Author(s)
Kawano Y, Nishiumi S, Tanaka S, Nobutani K, Miki A, Yano Y, Seo, Y, Ashida H, Kutsumi H, Azuma T, Yoshida M.
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Journal Title
Arch Biochem Biophys. 504
Pages: 221-227
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