The assessment of cancer/testis antigens whether they express the earlystage of cancer and use the targets for the diagnosis for early cancer.

2012 Fiscal Year Final Research Report

• Project/Area Number: 21700510
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Medical systems
• Research Institution: Kitasato University
• Principal Investigator: FUKUYAMA Takashi 北里大学, メディカルセンター, 上級研究員 (10462251)
• Project Period (FY): 2009 – 2012
• Keywords: 検査・診断システム / 癌/精巣抗原

Research Abstract

Cancer/testis antigens (CTAs) are the proteins expressing various types of cancer but not normal tissues except for germline cells. To assesse whether CTAs is appropriate for the diagnosis of cancer in early stage, I performed the immediate alteration of CTAs in the various cells exposed a carcinogen. I found that cells were started to express CTAs with not only exposure a carcinogen but also acquiring malignancy. Therefore we know that CTAs are fit for the target for diagnosis of early cancer because of the immediately expression with exposure of a carcinogen in conjunction with acquiring malignancy

Research Products

• [Journal Article] Helicobacter pylori, a carcinogen, induces the expression of melanoma antigen -coding gene(Mage) - A 3 , a cancer/testis antigen (2012)
  • Author(s): Fukuyama T. ,Yamazaki T . , Fujita T., Uematsu T., Ichiki Y., Kaneko H., Suzuki T . , Kobayashi N
  • Journal Title: Tumor Biology Volume: 33 Pages: 1881-1887
  • DOI: DOI10.1007/s13277-012-0448-6
• [Presentation] The induction of specific Cancer/Testis antigens expression by one carcinogen (2012)
  • Author(s): Takashi Fukuyama, Nobue Futawatari, Hitoshi Yamazaki, Taiga Yamazaki, Tomoko Fujita, Takayuki Uematsu, Mariko Ogi, Yoshihito Takahashi, Yatsushi Nishi, Yohei Yasogawa, Yoshinobu Ichiki1, Noritada Kobayashi
  • Organizer: 71st Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Sapporo
  • Year and Date: 2012-09-21
• [Presentation] Helicobacterpyloriによる特定の癌/精巣抗原の発現誘導の可能性 (2012)
  • Author(s): 福山隆 、二渡信江、山崎大賀、藤田智子、植松崇之、高橋禎人、西八嗣、山崎等、市来嘉伸、小林憲忠
  • Organizer: 第16回日本がん免疫学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-07-26
• [Presentation] Malignantly Transformation makes C3H/10T1/2 cells express Cancer/Testis antigen MAGE - A 3 (2011)
  • Author(s): Fukuyama T., Yamazaki T., Fujita T., Uematsu T., Ichiki Y., Kaneko H., Suzuki T., Kobayashi N
  • Organizer: 70th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Sapporo
  • Year and Date: 2011-10-03
• [Presentation] Helicobacter pylori is one carcinogenic factor and makes the MAGE-A3,one Cancer/Testis-antigenexpressed (2011)
  • Author(s): Fukuyama T. , Yamazaki T . , Fujita T . , Uematsu T. , IchikiY . , Kaneko H . , Suzuki T ., Kobayashi N
  • Organizer: The INTERNATIONAL UNION OF MICROBIOLOGICAL SOCIETIES 2011 Congress
  • Place of Presentation: Sapporo
  • Year and Date: 2011-09-10
• [Presentation] 癌/精巣抗原は早期癌診断の標的物質になり得るか? - 腫瘍細胞を用いた基礎的解析 - (2011)
  • Author(s): 福山隆、山崎大賀、藤田智子、植松崇之、市来嘉伸、金子博司、鈴木達夫、小林憲忠
  • Organizer: 第15回日本がん免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2011-06-30
• [Presentation] As for Cancer / Testis antigens whether it can use for the early diagnosis? (2009)
  • Author(s): 福山隆,小林憲忠,山崎大賀,清水智子,植松崇之,金子博司,鈴木達夫
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大 阪
  • Year and Date: 2009-12-03