2010 Fiscal Year Final Research Report
The combination therapy of mild-hyperthermia with therapeutic ultrasound and dendritic cell-based immunotherapy
| Project/Area Number |
21700511
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical systems
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| Research Institution | Teikyo University |
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Principal Investigator |
SUZUKI Ryo Teikyo University, 薬学部, 講師 (90384784)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 超音波 / リポソーム / がん温熱療法 / 樹状細胞 / がん免疫療法 / 低侵襲 |
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| Research Abstract |
Ultrasound (US) exposure to tumor tissue which was intratumorally injected nanobubbles (Bubble liposomes(BLs)), could induce anti-tumor effect by heating and shock waves derived from disruption of BLs. In addition, we found that strong tumor-specific immunity was induced by intratumoral injection of dendritic cells (DCs) after US therapy with BLs. The combination of US therapy with nanobubbles and DC-based immunotherapy efficiently suppressed tumor growth. Therefore, this might be a useful strategy for cancer therapy.
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