2010 Fiscal Year Final Research Report
Development of ultrasound molecular imaging with targeted-microbubbles
| Project/Area Number |
21700516
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Medical systems
|
|---|
| Research Institution | National Cardiovascular Center Research Institute |
|---|
Principal Investigator |
OTANI Kentaro 独立行政法人国立循環器病研究センター, 再生医療部, 流動研究員 (50470191)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 超音波医科学 |
|---|
| Research Abstract |
The feasibility of preparation method of antibody-carrying microbubbles based on the clinically available ultrasound contrast agent, Sonazoid was examined. By utilizing the Annexin V and avidin-biotin complex formation, the attachment of IgG antibodies onto the surface of Sonazoid bubbles was feasible. Although the further study should be required, the molecular targeted-bubbles based on Sonazoid might be applicable to the clinical settings for ultrasound molecular imaging in the near future.
|
