2011 Fiscal Year Final Research Report
Effect of ageing and exercise training on apha-actinin-3 in rat skeletal muscle
| Project/Area Number |
21700662
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Sports science
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
OGURA Yuji 聖マリアンナ医科大学, 医学部, 助教 (90509952)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 筋線維組成 / 加齢 / 骨格筋 |
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| Research Abstract |
The aim of this study was to clarify the effect of ageing and exercise training on α-actinin-3 in rat skeletal muscle. Our results suggest that ageing-induced muscle atrophy and fast-to-slow shift of the plantaris muscle accompanied with decrease in α-actinin-3, suggesting salcopenia might be associated with α-actinin-3.However, endurance exercise that we selected did not alter α-actinin-3 expression. Thus, endurance-type exercise may not be effective as intervention to α-actinin-3.
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