2011 Fiscal Year Final Research Report
Influence of PGC-1αand nuclear receptor gene polymorphisms on endurance performance and muscular mitochondria
| Project/Area Number |
21700666
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Sports science
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| Research Institution | Fukuoka University |
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Principal Investigator |
TOBINA Takuro 福岡大学, スポーツ科学部, 助教 (60509678)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 運動 / 骨格筋 / 遺伝子多型 / 核内受容体 |
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| Research Abstract |
Present study investigate whether the gene polymorphisms of PGC-1 and nuclear receptor affects endurance performance and muscular mitochondrial content. The Gly/Gly+Gly/Ser of PGC-1αgene polymorphism, and T/T+T/C of PPARδ gene T294C polymorphism, are significantly higher endurance performance than that of Ser/Ser and C/C, respectively. In exercise training study, the decrease of LDL cholesterol is greater in Gly/Gly than the Gly/Ser, and Ser/Ser. The improvement of lactate threshold intensity is higher in T/T than the T/C, and C/C.
However, those polymorphisms are not affected in muscular mitochondrial content.
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Research Products
(5 results)
