2010 Fiscal Year Final Research Report
Effects of a soybean isoflavone metabolite on male osteoporosis and the elucidation of its mechanism
| Project/Area Number |
21700712
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | National Institute of Health and Nutrition |
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Principal Investigator |
TOUSEN Yuko National Institute of Health and Nutrition, 食品保健機能プログラム, 流動研究員 (20360092)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 骨粗鬆症 / 大豆イソフラボン / エクオール / 骨密度 / 破骨細胞 / 骨芽細胞 / アポトーシス / エストロゲン |
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| Research Abstract |
The administration of equol (0.50 mg/day) for 4 weeks inhibited tibial bone loss, and markers of bone resorption tended to decrease in orchiectomized mice. Furthermore, equol significantly inhibited the osteoclast formation induced by RANKL (receptor activator of NF-kappaB ligand) in a dose-dependent manner (0.1-50 μM) in RAW 264 cells and promoted the activities of caspase 3/7 in RAW 264 cell-derived mature osteoclasts. These results suggest that equol improves the bone metabolism in male osteoporotic patients, and the inhibition of bone resorption may contribute to the improvement of bone metabolism.
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