2011 Fiscal Year Final Research Report
Involvement of microRNA in osteoblast differentiation, and its application
| Project/Area Number |
21700715
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | Kinki University (2011)
Gifu International Institute of Biotechnology (2009-2010) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 加齢・老化 / microRNA / 骨芽細胞 / 分化 |
|---|
| Research Abstract |
In this study, we found that the expression levels of 9 miRNAs(log ratio, 1.5<) were distinct between BMP-2-treated and nontreated cells. Among these, we showed that Dlx5, Ets1 BMP-2 and Ets1 genes were regulated by miR-141/-200a, miR-208, and miR-370, respectively. The above-mentioned results strongly suggests that miRNAs has been closely involved in BMP-2-induced osteoblast differentiation.
|
