2011 Fiscal Year Final Research Report
Primary Prevention of Metabolic Syndrome : Aging-related gene with Reactive Oxygen Species
| Project/Area Number |
21700754
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nara Women's University |
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Principal Investigator |
NEGISHI Hiroko 奈良女子大学, 大学院人間文化研究科, 助教 (50523841)
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| Project Period (FY) |
2009 – 2011
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| Keywords | メタボリックシンドローム / UCP2 / 活性酸素種 / NOS / イソフラボン / 疾患モデル動物 |
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| Research Abstract |
Metabolic syndrome (MS) is associated with overproduction of reactive oxygen species (ROS). The increase of UCP2mRNA expression may depend on increased oxdative stress in SHRSP.Z-Lepr^<fa/>Izm Dmcr rats (SP・ZF). The increase of UCP2 mRNA expression may relate to the phenotype in metabolic syndrome status in SP・ZF. We observed that kudzu extracts could decrease body weight, blood pressure, and serum lipids significantly by increasing UCPs, PPARs.
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Research Products
(11 results)
