2010 Fiscal Year Final Research Report
The novel effect of polyphenolic diterpene in rosemary, activating oxidative stress sensor
| Project/Area Number |
21700756
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Shujitsu Junior College (2010)
Hiroshima University (2009) |
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Principal Investigator |
KAYASHIMA Tomoko Shujitsu Junior College, 生活科学科, 講師 (90452599)
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| Project Period (FY) |
2009 – 2010
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| Keywords | カルノシン酸 / 抗酸化 / 血管新生 / 血管内皮細胞 / ローズマリー |
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| Research Abstract |
In this study, the effect of carnosic acid (CA) activating Keap1/Nrf2 pathway, a polyphenolic diterpene in rosemary, on angiogenesis was examined. CA suppressed microvessel outgrowth in an ex vivo serum-free matrix culture model using a rat aortic. The antiangiogenic effect of CA was shown in angiogenesis models using human umbilical vein endothelial cells with regard to tube formation on reconstituted basement membrane, proliferation and chemotaxis. These results suggest that CA may be useful for prevention and treatment of angiogenesis-dependent disorders.
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