2010 Fiscal Year Final Research Report
Protective effects of rutin against toxicant-induced memory dysfunction and elucidation of the molecular mechanisms
| Project/Area Number |
21700758
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Eating habits, studies on eating habits
|
|---|
| Research Institution | Tokyo Health Care University (2010)
University of Miyazaki (2009) |
|---|
Principal Investigator |
KODA Tomoko Tokyo Health Care University, 看護学部, 講師 (30391098)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 食品 / 神経科学 |
|---|
| Research Abstract |
Rutin is one of flavonoids and buckwheat is known as a major source of rutin. We demonstrated that oral administration of rutin has a protective effect against trimethyltin (TMT)-induced memory dysfunction in rats. Furthermore, we suggested that anti-inflammatory function of rutin revealed protective effects against TMT-induced neuron loss in the hippocampus which plays an important role in memory using cellular and molecular biological techniques.
|
