2011 Fiscal Year Final Research Report
Functional food to help reduce the risk of diabetic complications
| Project/Area Number |
21700765
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Eating habits, studies on eating habits
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
ITO Tomoko (OYA Tomoko) 京都府立医科大学, 医学研究科, 准教授 (80329648)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 健康と食生活 / 糖尿病合併症 / 酸化ストレス / 消化管 / 消化管 / プロテオミクス解析 / 翻訳後修飾 / がん |
|---|
| Research Abstract |
Methylglyoxal (MG), an endogenous metabolite that increases in diabetes and is a common intermediate in the Maillard reaction (glycation), reacts with proteins and forms advanced glycation end products. (1) By using a monoclonal antibody to MG-modified proteins, we found that heat-shock protein 27 (Hsp27) was modified by MGin ascending colon and rectum of patients with cancer. However, MG-modified Hsp25/Hsp27 was not detected in non cancerous cell lines or in normal subject. (2) Many tea extracts and antioxidants inhibited both generation of reactive oxygen species and impaired phagocytosis in neutrophils under high glucose condition. It is expected that a number of antioxidant can prevent the development of diabetes and inflammatory disease.
|
-
-
[Journal Article] Hemopexin is upregulated in rat intestinal mucosa injured by indomethacin2012
Author(s)
Takagi T, Naito Y, Okada H, Takaoka M, Oya-Ito T, Yamada S, Hirai Y, Mizushima K, Yoshida N, Kamada K,Katada K, Uchiyama K, Ishikawa T, Handa O, Yagi N, Konishi H, Kokura S, Ichikawa H, Yoshikawa T
-
Journal Title
J Gastroenterol Hepatol
Volume: J Gastroenterol Hepatol
Pages: 70-75
DOI
Peer Reviewed
-
[Journal Article] Detection of N-(hexanoyl)lysine in the tropomyosin 1 protein in N-methyl-N'-nitro-Nnitrosoguanidine-induced rat gastric cancer cells2012
Author(s)
Okada H, Naito Y, Takagi T, Takaoka M, Oya-Ito T, Fukumoto K, Uchiyama K, Handa O, Kokura S, Nagano Y, Matsui H, Kato Y, Osawa T, Yoshikawa T
-
Journal Title
J Clin Biochem Nutr
Volume: vol.50、No.1
Pages: 47-52
DOI
Peer Reviewed
-
-
-
-
[Journal Article] Identification of dihalogenated proteins in rat intestinal mucosa injured by indomethacin2011
Author(s)
Takagi T, Naito Y, Okada H, Okayama T,Mizushima K, Yamada S, Fukumoto K, Inoue K, Takaoka M, Oya-Ito T, Uchiyama K, Ishikawa T, Handa O, Kokura S, Yagi N, Ichikawa H, Kato Y, Osawa T, Yoshikawa T
-
Journal Title
J Clin Biochem Nutr
Volume: vol. 48、No.2
Pages: 178-182
DOI
Peer Reviewed
-
[Journal Article] Impaired gastric ulcer healing in diabetic mice: role of methylglyoxal2009
Author(s)
Naito Y, Takagi T, Oya-Ito T, Okada H, Suzuki T, Hirata I, Hirai M, Uchiyama K, Handa O, Uchida K, Yoshikawa T
-
Journal Title
J Physiol Pharmacol
Volume: vol.60
Pages: 123-130
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Identification of Dihalogenated Proteins involved in Rat Intestinal Mucosa Injured by Indomethacin2010
Author(s)
Yoriki H, Naito Y, Takagi T, Handa O, Okada H, Oya-Ito T, Uchiyama K, Ichikawa H, Kato Y, Osawa T, Yoshikawa T
Organizer
SFRBM's 17th Annual Meeting
Place of Presentation
Caribe Royale Hotel & Conference Center(Orland, USA)
Year and Date
2010-11-19
-
[Presentation] Identification of acrolein modified proteins Involved in the pathogenesis of delayed gastric ulcer healing in diabetic mice2010
Author(s)
Horie R, Naito Y, Takagi T, Handa O, Oya-Ito T, Okada H, Uchiyama K, Ichikawa H, Uchida K, Yoshikawa T
Organizer
SFRBM's 17th Annual Meeting
Place of Presentation
Caribe Royale Hotel & Conference Center(Orland, USA)
Year and Date
2010-11-19
-
-
-
-
-
-
-
-
-
[Presentation] Identification of Acrolein Modified Proteins in the Gastric Ulcer Mucosa of Diabetic Mice2010
Author(s)
Takagi T, Naito Y, Oya-Ito T, Suzuki T, Mizushima K, Hayashi N, Hirata I, Okada H, Horie R, Yoshida N, Uchiyama K, Uchiyama K, Ishikawa T, Handa O, Konishi H, Wakabayashi N, Yagi N, Kokura S, Ichikawa H, Yoshikawa T
Organizer
2010 Digestive Disease Week
Place of Presentation
New Orleans, USA.
Year and Date
2010-05-05
-
-
-
[Presentation] The expression of peroxiredoxin-vi (prxvi) in murine dextran sodium sulfate (DSS)-induced colitis2009
Author(s)
Takagi T, Naito Y, Omatsu T, Okada H, Oya-Ito T, Mizushima K, Hayashi N, Hirai Y, Harusato A, Fukumoto K, Yamada S, Inoue K, Horie R, Hirata I, Ishikawa T, Handa O, Kokura S, Ichikawa H, Yoshikawa T
Organizer
5th Joint Meeting of The Societies for Free Radical Research Australasia and Japan
Place of Presentation
VeterinaryScience Conference Centre, University of Sydney (Sydney, Australia)
Year and Date
2009-12-01
-
[Presentation] Proteomic discovery of the down-regulation of peroxiredoxin-6 in murine dextran sodium sulfate-induced colitis2009
Author(s)
Omatsu T, Naito Y, Takagi T, Mizushima K, Okada H, Inoue K, Yamada S, Fukumoto K, Harusato A, Hirata I, Oya-Ito T, Uchiyama K, Handa O, Yagi N, Kokura S, Ichikawa H, Yoshikawa T
Organizer
The United European Gastroenterology Week 2009
Place of Presentation
ExCeL London (London, UK)
Year and Date
2009-11-24
-
-
-
-
[Presentation] The exhaustive proteomics revealed the down-regulation of peroxiredoxin-6 in murine dextran sodium sulfate-induced colitis2009
Author(s)
Omatsu T, Naito Y, Takagi T, Mizushima K, Okada H, Inoue K, Yamada S, Fukumoto K, Harusato A, Hirata I, Oya-Ito T, Handa O, Yagi N, Kokura S, Ichikawa H, Yoshikawa T
Organizer
The 14th International Congress of Mucosal Immunology
Place of Presentation
Marriott Boston Copley Place (Boston, USA)
Year and Date
2009-07-07
-
-
[Presentation] Decreased expression of peroxiredoxin-6 in murine dextran sodium sulfate-induced colitis identified by 2-dimensional fluorescence difference in gel electrophoresis2009
Author(s)
Omatsu T, Naito Y, Takagi T, Mizushima K, Okada H, Fukumoto K, Harusato A, Hirata I, Hamano Y, Oya-Ito T, Handa O, Yagi N, Kokura S, Ichikawa H, Fujiwake H, Yoshikawa T
Organizer
The 110th Annual Meeting of the AGA Institute.Digestive Disease Week
Place of Presentation
Chicago, USA
Year and Date
2009-05-31
-
-
