2010 Fiscal Year Final Research Report
Specific of vitamin E metabolic tissue and influence of sesame on vitamin E metabolizing in rat.
| Project/Area Number |
21700771
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nagoya University of Arts and Sciences |
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Principal Investigator |
UCHIDA Tomono Nagoya University of Arts and Sciences, 管理栄養学部, 助手 (50440821)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 食と栄養 |
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| Research Abstract |
Vitamin E(Tocopherol ; Toc) is a fat-soluble and Vitamin E is metabolized with the liver. It has not been clarified before that Toc is metabolized in the extrahepatic tissue. The aim of this study was to determine if Toc isoforms were metabolized in extrahepatic tissue. It as result, Toc is metabolized via cytochrome P450-dependent pathway in the intestine during absorption. And it was clarified an excessive amount of α-Toc promotes metabolizing γ-Toc. In addition, it is suggest that dietary sesame seed inhibits not only γ-Toc metabolism to γ-CEHC but also α-Toc metabolism to α-CEHC in rats.
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