2012 Fiscal Year Final Research Report
Cancer Preventive Effects of Resveratrol Oligomer-Rich Food Factors with an Antiangiogenic Activity
| Project/Area Number |
21700773
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | 公益財団法人がん研究会 (2012)
Mukogawa Women's University (2009-2011) |
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Principal Investigator |
KUNIMASA Kazuhiro 公益財団法人がん研究会, がん化学療法センターゲノム研究部, 研究員 (50534020)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 血管新生 / 血管内皮細胞 / がん / レスベラトロール / 食品機能 / マイクロアレイ |
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| Research Abstract |
In in vitro angiogenesis models, the melinjo (Gnetum gnemon L.) seed extract and its major component gnetin C, a resveratrol dimer, inhibited multiple angiogenic functions, such as endothelial cell proliferation, migration, and tube formation. The melinjo extract also suppressed tumor angiogenesis, growth, and metastasis in vivo. Furthermore, using a gene expression signature-based approach, the modes of action of the melinjo extract and gnetin C were found to be similar to those of topoisomerase and cyclin-dependent kinase inhibitors
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Research Products
(20 results)
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[Journal Article] Resveratrol derivative-rich melinjo (Gnetum gnemon L.) seed extract suppresses multiple angiogenesis-related endothelial cell functions and tumor angiogenesis2011
Author(s)
Kunimasa K, Ohta T, Tani H, Kato E, Eguchi R, Kaji K, Ikeda K, Mori H, Mori M, Tatefuji T, Yamori Y
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Journal Title
Mol Nutr Food Res
Volume: 55(11)
Pages: 1730-4
DOI
Peer Reviewed
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