The effect of pesticides on mammalian immune system

2010 Fiscal Year Final Research Report

• Project/Area Number: 21710034
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Environmental impact assessment/Environmental policy
• Research Institution: Ehime University
• Principal Investigator: NISHIMOTO Sogo Ehime University, 沿岸環境科学研究センター・グローバル, COE研究員 (70392066)
• Project Period (FY): 2009 – 2010
• Keywords: 健康影響評価 / 免疫撹乱化学物質

Research Abstract

In this research, we investigated the influence of endosulfan used in various countries on mammalian immune system, especially allergy response. Endosulfan increased the amount of antigen-specific IgE in serum from allergy-induced mice. Moreover, endosulfan enhanced the IL-4 production in serum and splenocytes culture medium. Endosulfan not only induced the initiation of allergy response, but also stimulated the release of chemical mediator as inflammatory substances. We suggested that the effect of endosulfan was concerned with both initiation and inflammation.

Research Products

• [Journal Article] The effects of pesticides on immune cells. (2009)
  • Author(s): Nishimoto, S., Kanda, K., Okabe, M., Akiyama, K., Kakinuma, Y., Sugahara, T.
  • Journal Title: Animal Cell Technology : Basic, Applied Aspects 1 6 Pages: 377-381
• [Journal Article] Heavy oil fractions induce the negative influences on mouse immune system. (2009)
  • Author(s): Nishimoto, S., Kanda, K., Yamawaki, M., Okabe, M., Akiyama, K., Kakinuma, Y., Sugahara, T.
  • Journal Title: The Journal of Toxicological Sciences 3 4 Pages: 459-468
  • Peer Reviewed
• [Journal Article] abnormalities in the reproductive organs of mice caused by chemical substances in heavy oil. (2009)
  • Author(s): Nishimoto, S., Yamawaki, M., Akiyama, K., Kakinuma, Y., Kitamura, S-I., Sugahara, T.Severe
  • Journal Title: The Journal of Toxicological Sciences 3 4 Pages: 239-324
  • Peer Reviewed
• [Journal Article] Abnormal response induced by pesticides in mammalian immune system. (2009)
  • Author(s): Nishimoto, S., Kanda, K., Okabe, M., Akiyama, K., Kakinuma, Y., Sugahara, T.
  • Journal Title: Interdisciplinary Studies on Environmental Chemistry 2 Pages: 211-217
  • Peer Reviewed
• [Presentation] エンドスルファンが雄マウスの生殖系に及ぼす影響 (2011)
  • Author(s): 細羽康介、西本壮吾、中田雄一郎、柿沼喜己、菅原卓也
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-27
• [Presentation] オルトフェニルフェノールの生体毒性について (2011)
  • Author(s): 中田雄一郎、西本壮吾、柿沼喜己、細羽康介、菅原卓也
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-27
• [Presentation] The risk assessment of chemical substances in heavy oil on mammalian reproductive organs. (2010)
  • Author(s): Nishimoto, S., Akiyama, K., Kakinuma, Y., Sugahara, T.
  • Organizer: The 5th Global COE international Symposium.Modeling and Analysis of Marine Environmental Problems
  • Place of Presentation: Matsuyama, Japan.
  • Year and Date: 2010-09-22
• [Presentation] Endosulfan exaggerates allergy symptoms. (2010)
  • Author(s): Sugahara, T., Nishimoto, S., Atobe, S., Hosoba, K., Kakinuma, Y.
  • Organizer: The 5th Global COE international Symposium.Modeling and Analysis of Marine Environmental Problems.
  • Place of Presentation: Matsuyama, Japan
  • Year and Date: 2010-09-22
• [Presentation] Influence of endosulfan on allergic response in mouse. (2010)
  • Author(s): Nishimoto, S., Atobe, S., Okabe, M., Akiyama, K., Kakinuma, Y., Sugahara, T.
  • Organizer: The 14th International Biotechnology Symposium and Exhibition.P-M.64,
  • Place of Presentation: Rimini, Italy
  • Year and Date: 2010-09-14
• [Presentation] Influence of chemical compounds in heavy oil on mouse reproductive system. (2010)
  • Author(s): Nishimoto, S., Okabe, M., Akiyama, K., Kakinuma, Y., Sugahara, T.
  • Organizer: The 23th Annual and International Meeting of the Japanese Association for Animal Cell Technology, p.215.
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2010-09-03
• [Presentation] Effect of endosulfan on allergic response. (2010)
  • Author(s): Sugahara, T., Nishimoto, S., Atobe, S., Hosoba, K., Kakinuma, Y.
  • Organizer: The 23th Annual and International Meeting of the Japanese Association for Animal Cell Technology, p.211.(2010)
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2010-09-03
• [Presentation] 重油水溶性画分がマウス生殖系に及ぼす影響 (2010)
  • Author(s): 西本壮吾、岡部正明、秋山浩一、柿沼喜己、菅原卓也
  • Organizer: 日本農芸化学会2010年度大会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-28
• [Presentation] β-endosulfan のマウス免疫系に与える影響 (2010)
  • Author(s): 跡部聡子、西本壮吾、岡部正明、柿沼喜己、菅原卓也
  • Organizer: 日本農芸化学会2010年度大会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-28