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2010 Fiscal Year Final Research Report

Analysis of the molecular mechanisms of acquired radioresistance induced by fractionated radiation

Research Project

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Project/Area Number 21710054
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Risk sciences of radiation/Chemicals
Research InstitutionTohoku University

Principal Investigator

SHIMURA Tsutomu  Tohoku University, 加齢医学研究所, 助教 (40463799)

Project Period (FY) 2009 – 2010
Keywords放射線 / がん
Research Abstract

We have demonstrated that tumor radioresistance can be suppressed by down-regulation of AKT/GSK3beta/cyclin D1 pathway. Manipulation of cyclin D1 is useful to enhance the efficacy of radiotherapy.

  • Research Products

    (11 results)

All 2011 2010 2009 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Targeting the AKT/GSK3b/cyclin D1/Cdk4 survival signaling pathway for eradication of tumor radioresistance acquired by fractionated radiotherapy2011

    • Author(s)
      Shimura T, Kakuda S, Ochiai Y, Kuwahara Y, Takai Y, Fukumoto M.
    • Journal Title

      International Journal of Radiation Oncology Biology Physics 80

      Pages: 540-548

    • Peer Reviewed
  • [Journal Article] Interactions of MCP1 with Components of the Replication Machinery in Mammalian Cells.2011

    • Author(s)
      Bronze-da-Rocha E, Lin CM, Shimura T, Aladjem MI.
    • Journal Title

      Int J Biol Sci 7

      Pages: 193-208

    • Peer Reviewed
  • [Journal Article] Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3beta-mediated cyclin D1 overexpression.2010

    • Author(s)
      Shimura T, Kakuda S, Ochiai Y, Nakagawa H, Kuwahara Y, Takai Y, Kobayashi J, Komatsu K, Fukumoto M.
    • Journal Title

      Oncogene 29

      Pages: 4826-4837

    • Peer Reviewed
  • [Journal Article] X-radiation-induced down-regulation of the EGF receptor in primary cultured rat hepatocytes.2010

    • Author(s)
      Maruko A, Ohtake Y, Kawaguchi M, Kobayashi T, Baba T, Kuwahara Y, Nakagawa H, Shimura T, Fukumoto M, Ohkubo Y.
    • Journal Title

      Radiat Res 173

      Pages: 620-628

    • Peer Reviewed
  • [Journal Article] The modified high-density survival assay is the useful tool to predict the effectiveness of fractionated radiation exposure.2010

    • Author(s)
      Kuwahara Y, Mori M, Oikawa T, Shimura T, Ohtake Y, Mori S, Ohkubo Y, Fukumoto M.
    • Journal Title

      J Radiat Res (Tokyo) 51

      Pages: 297-302

    • Peer Reviewed
  • [Journal Article] Clinically relevant radioresistant cells efficiently repair DNA double-strand breaks induced by X-rays.2009

    • Author(s)
      Kuwahara Y, Li L, Baba T, Nakagawa H, Shimura T, Yamamoto Y, Ohkubo Y, Fukumoto M.
    • Journal Title

      Cancer Sci 100

      Pages: 747-752

    • Peer Reviewed
  • [Presentation] AKT阻害剤とCdk4阻害剤によるヒトがん細胞の放射線耐性の抑制2010

    • Author(s)
      志村勉、角田智、落合泰史、桑原義和、高井良尋、福本学
    • Organizer
      日本放射線影響学会
    • Place of Presentation
      京
    • Year and Date
      2010-10-21
  • [Presentation] DNA-PK/ATK/GSK3β/Cyclin D1経路を標的としたヒトがん細胞の獲得放射線耐性の克服2010

    • Author(s)
      志村勉、桑原義和、高井良尋、福本学
    • Organizer
      日本癌学会
    • Place of Presentation
      都
    • Year and Date
      2010-09-24
  • [Presentation] DNA-PK/AKT/GSK3b/cyclinD1経路を標的としたヒトがん細胞における放射線耐性の克服2009

    • Author(s)
      志村勉、角田智、高井良尋、桑原義和、福本学
    • Organizer
      日本放射線影響学会
    • Place of Presentation
      広島
    • Year and Date
      2009-11-11
  • [Presentation] 長期分割放射線被ばくによるがん細胞の放射線耐性の獲得2009

    • Author(s)
      志村勉、落合泰史、桑原義和、福本学
    • Organizer
      日本放射線影響学会
    • Place of Presentation
      広島
    • Year and Date
      2009-11-11
  • [Remarks] ホームページ等

    • URL

      http://www.idac.tohoku.ac.jp/ja/organization/pathology/index.html

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Published: 2012-02-13   Modified: 2016-04-21  

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