The study of clinically relevant radioresistant cells for the development of more effective tumor radiotherapy

2010 Fiscal Year Final Research Report

• Project/Area Number: 21710055
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Tohoku University
• Principal Investigator: KUWAHARA Yoshikazu 東北大学, 加齢医学研究所, 助教 (00392225)
• Project Period (FY): 2009 – 2010
• Keywords: 放射線耐性 / オートファジー細胞死 / ラパマイシン

Research Abstract

X-ray induced autophagic cell death is suppressed in radioresistant cells. Administration of rapamycin, an induced of autophagy, sensitized radioresistant cells. Induction of autophagy would be the effective modality to overcome radioresistant tumor.

Research Products

• [Journal Article] Targeting the AKT/GSK3β/Cyclin D1/Cdk4 Survival Signaling Pathway for Eradication of Tumor Radioresistance Acquired by Fractionated Radiotherapy (2011)
  • Author(s): Shimura T, Kakuda S, Ochiai Y, Kuwahara Y, Takai Y, Fukumoto M
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 80 Pages: 540-548
  • Peer Reviewed
• [Journal Article] The uneven irradiation of a target cell and its dynamic movement can mathematically explain incubation period for the induction of cancer by internally deposited radionuclides (2010)
  • Author(s): Yamamoto Y, Usuda N, Oghiso Y, Kuwahara Y, Fukumoto M
  • Journal Title: Health Phys. Volume: 99 Pages: 388-393
  • Peer Reviewed
• [Journal Article] Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3beta-mediated cyclin D1 overexpression (2010)
  • Author(s): Shimura T, Kakuda S, Ochiai Y, Nakagawa H, Kuwahara Y, Takai Y, Kobayashi J, Komatsu K, Fukumoto M
  • Journal Title: Oncogene Volume: 29 Pages: 4826-4837
  • Peer Reviewed
• [Journal Article] X-radiation-induced down-regulation of the EGF receptor in primary cultured rat hepatocytes (2010)
  • Author(s): Maruko A, Ohtake Y, Kawaguchi M, Kobayashi T, Baba T, Kuwahara Y, Nakagawa H, Shimura T, Fukumoto M, Ohkubo Y
  • Journal Title: Radiat Res. Volume: 173 Pages: 620-628
  • Peer Reviewed
• [Journal Article] The modified high-density survival assay is the useful tool to predict the effectiveness of fractionated radiation exposure (2010)
  • Author(s): Kuwahara Y, Mori M, Oikawa T, Shimura T, Ohtake Y, Mori S, Ohkubo Y, Fukumoto M
  • Journal Title: J Radiat Res. Volume: 51 Pages: 297-302
  • Peer Reviewed
• [Journal Article] Enhancement of autophagy is a potential modality for tumors refractory to radiotherapy
  • Author(s): Kuwahara Y, Oikawa T, Ochiai Y, Roudkenar MH, Fukumoto M, Shimura T, Ohtake Y, Ohkubo Y, Mori S, Uchiyama Y, Fukumoto M
  • Journal Title: Cell Death and Disease Volume: (in press)
  • Peer Reviewed
• [Journal Article] Neutrophil gelatinase-associated lipocalin: A new antioxidant that exerts its cytoprotective effect independent on Heme Oxygenase-1
  • Author(s): Roudkenar MH, Halabian R, Bahmani P, Roushandeh AM, Kuwahara Y, Fukumoto M
  • Journal Title: Free Radical Research Volume: (in press)
  • Peer Reviewed
• [Presentation] Are radioresistant cells chemoresistant?: Examined by clinically relevant radioresistant cells (2009)
  • Author(s): KUWAHARA Y, OIKAWA T, MORI M, FUKUMOTO M, KURIHARA A, SHIMURA T, FUKUMOTO M
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20091001-03
• [Remarks]
  • URL: http://www.idac.tohoku.ac.jp/dep/path/