Molecular function of radiation-induced mammary carcinoma-related genes/microRNAs in three dimensional culture system

2010 Fiscal Year Final Research Report

• Project/Area Number: 21710058
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Hiroshima University
• Principal Investigator: IIZUKA Daisuke Hiroshima University, 原爆放射線医科学研究所, 助教 (00455388)
• Project Period (FY): 2009 – 2010
• Keywords: 放射線誘発乳がん / 三次元培養 / マイクロRNA

Research Abstract

In this study, I focused on radiation-induced mammary carcinoma-related genes/microRNAs, and I analyzed whether these genes/microRNAs formed aberrant mammary ductal structure in three dimensional culture systems. The aberrant mammary ductal structure was not observed by introducing these microRNAs in MCF-10A cells, suggesting that these microRNAs have no function at least on the formation of mammary duct.

Research Products

• [Journal Article] DNA copy number aberrations and disruption of the p16Ink4a/Rb pathway in radiation-induced and spontaneous rat mammary carcinomas. (2010)
  • Author(s): Iizuka D., Imaoka T., Takabatake T., Nishimura M., Kakinuma S., Nishimura Y., Shimada Y.
  • Journal Title: Radiation Research 174(2) Pages: 206-215
  • Peer Reviewed
• [Journal Article] Radiation-induced mammary carcinogenesis in rodent models: what's different from chemical carcinogenesis? (2009)
  • Author(s): Imaoka T, Nishimura M, Iizuka D, Daino K, Takabatake T, Okamoto M, Kakinuma S, Shimada Y.
  • Journal Title: Journal of Radiation Research 50(4) Pages: 281-293
  • Peer Reviewed
• [Presentation] ラット放射線誘発乳がんに特徴的なマイクロRNA が乳がん細胞株に与える影響 (2010)
  • Author(s): 飯塚大輔, 今岡達彦, 西村まゆみ, 河合秀彦, 鈴木文男, 島田 義也
  • Organizer: 第53回日本放射線影響学会
  • Place of Presentation: 京都テルサ(京都市)
  • Year and Date: 2010-10-20
• [Presentation] ラット放射線誘発乳がんにおけるマイクロRNA 発現の網羅的解析 (2009)
  • Author(s): 飯塚大輔, 今岡達彦, 西村まゆみ, 高畠貴志, 柿沼志津子, 河合秀彦, 鈴木文男, 島田義也
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2009-12-11
• [Presentation] ラット乳がんにおける放射線被ばくに特徴的なマイクロRNA の解析 (2009)
  • Author(s): 飯塚大輔, 今岡達彦, 西村まゆみ, 高畠貴志, 柿沼志津子, 河合秀彦, 鈴木文男, 島田義也
  • Organizer: 第52回日本放射線影響学会
  • Place of Presentation: 南区民文化センター(広島市)
  • Year and Date: 2009-11-12
• [Presentation] 放射線誘発ラット乳がんにおけるmicroRNA 解析 (2009)
  • Author(s): 飯塚大輔, 今岡達彦, 西村まゆみ, 高畠貴志, 柿沼志津子, 河合秀彦, 鈴木文男, 島田義也
  • Organizer: 第148回日本獣医学会
  • Place of Presentation: とりぎん文化会館(鳥取市)
  • Year and Date: 2009-09-26