2010 Fiscal Year Final Research Report
Analyses of mammalian ribonecleoproteome dynamics via modified SELEX procedure.
| Project/Area Number |
21710191
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
基礎ゲノム科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OHUCHI Shoji The University of Tokyo, 医科学研究所, 助教 (20422412)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ゲノム調節 |
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| Research Abstract |
In order to identify natural RNA elements which interact with intracellular proteins, I performed the modified SELEX procedure coupled with in silico screening employing whole human transcriptome library, and found the interactions between a transcription elongation regulator protein, HEXIM1, and several mRNAs. The result indicates the presence of a novel class of post-transcriptional gene regulatory mechanism mediated via RNA-protein interactions.
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