2010 Fiscal Year Final Research Report
Analysis of Transcriptional Regulation of Genome by Pathogenicity Transcription Factor LeuO.
Project/Area Number |
21710198
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
基礎ゲノム科学
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Research Institution | Hosei University |
Principal Investigator |
SHIMADA Tomohiro Hosei University, マイクロ・ナノテクノロジー研究センター, 研究員 (10535230)
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Project Period (FY) |
2009 – 2010
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Keywords | ゲノム発現制御 / 転写 / 病原性細菌 / 転写因子LeuO / Genomic SELEX / 薬剤耐性 / サルファ剤耐性遺伝子 |
Research Abstract |
To get insights into the regulatory role(s) of LeuO, attempts were made to identify the whole set of regulation targets using Genomic SELEX system. A total of 140 LeuO-binding sites were identified on the E.coli genome, 125 of which were newly identified. Taken together with our previous finding of the involvement of LeuO in mutli-drug efflux, it was revealed that LeuO regulates a number of genes for biofilm formation including the genes for fimbriae formation.
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Research Products
(13 results)
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[Presentation] Growth phase-dependent regulation of csgD, the master regulator of biofilm formation : Interplay between multiple transcription factors.2009
Author(s)
Ishihama, A., Ogasawara, H., Shimada, T., Teramoto, J., Kori,A., Yamada, K., Yamamoto, K.
Organizer
3^<rd> Internatl. Conf. Environmental, Industrial and Applied Microbiology (BioMicroWorld 2009)
Place of Presentation
Lisbon, Portugal.
Year and Date
20090000
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