2010 Fiscal Year Final Research Report
Biosynthetic study of polyether skeleton : functional analysis of epoxidase and epoxide hydrolase.
| Project/Area Number |
21710213
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Hokkaido University |
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Principal Investigator |
MINAMI Atsushi Hokkaido University, 大学院・理学研究院, 助教 (40507191)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ポリエーテル / 生合成 / エポキシド加水分解酵素 / エポキシ化酵素 |
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| Research Abstract |
Functional analysis of two enzymes, epoxidase and epoxide hydrolase, involved in ionophore polyether biosynthesis advances our understanding of the enzymatic asymmetric epoxidation and epoxide-opening cascades. These findings open the door for the enzymatic synthesis of polyether skeleton.
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[Journal Article] Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis.2011
Author(s)
Minami, A., Migita, A., Inada, D., Hotta, K., Watanabe, K., Oguri, H., Oikawa, H.
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Journal Title
Peer Reviewed
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[Presentation] Detailed Mechanism of Polyether Ring Formation Catalyzed by Epoxide Hydrolase Lsd19 involved in Lasalocid A biosynthesis2010
Author(s)
Minami, A., Migita, A., Inada, D., Watanabe, K., Oguri, H., Oikawa, H.
Organizer
PACIFICHEM 2010
Place of Presentation
Convention Center(ホノルル、米国)
Year and Date
2010-12-17
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