2010 Fiscal Year Final Research Report
Exploration of Innate Immune Regulators from Microorganisms
| Project/Area Number |
21710215
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2010
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| Keywords | 天然物化学 / 自然免疫 / 二次代謝産物 / 生物活性物質 / ケミカルバイオロジー |
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| Research Abstract |
To screen pharmaceuticals that target innate immunity, we established an ex vivo culture system based on the innate immune response of Drosophila, which is highly useful for identifying immune regulators that act on human innate immunity. We used this system to search for natural substances that regulate innate immunity, and identified aspergillicin E and gonytolide A as a potent suppressor and an activator, respectively. In addition, we synthesized some derivatives of celastramycin A to evaluate structure-activity relationship of these compounds.
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