2010 Fiscal Year Final Research Report
Analysis on a novel receptor/signaling pathway regulating tight junction and its application
| Project/Area Number |
21710219
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
NAGUMO Yoko University of Tsukuba, 大学院・生命環境科学研究科, 助教 (70373339)
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| Project Period (FY) |
2009 – 2010
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| Keywords | タイトジャンクション / コフィリン / 生理活性 |
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| Research Abstract |
We previously found that capsaicin induces tight-junction (TJ) opening accompanied with cofilin activation in intestinal Caco-2 cells. In order to clarify the mechanism underlying the TJ opening action of capsaicin, I analyzed upstream and downstream of cofilin. As a result, I found proteins suggested to function leading to cofilin activation. In addition, I demonstrated that actin cytoskeleton, that is a direct target of cofilin, is remodeling together with some other proteins. I also investigated molecules which permeability is increased by capsaicin.
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[Journal Article] Trastuzumab and pertuzumab produce changes in morphology and estrogen receptor signaling in ovarian cancer xenografts revealing new treatment strategies.
Author(s)
Dana FARATIAN, Annelien ZWEEMER, Yoko NAGUMO, Andrew SIMS, Morwenna MUIR, Michael DODDS, Peter MULLEN, InHwa UM, Charlene KAY, Max HASMANN, David J.HARRISON, Simon P.LANGDON
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Journal Title
Clin.Cancer Res. in press.
Peer Reviewed
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