2010 Fiscal Year Final Research Report
Control of amyloidogenic proteins using surface-engineered β-barrel proteins
| Project/Area Number |
21710225
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Gunma University (2010)
Tokyo Institute of Technology (2009) |
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Principal Investigator |
TAKAHASHI Tsuyoshi Gunma University, 先端科学研究指導者育成ユニット, 准教授 (90345380)
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| Project Period (FY) |
2009 – 2010
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| Keywords | アミロイドβペプチド / ポリグルタミンタンパク質 / βバレルタンパク質 / タンパク質工学 / 神経変性疾患 / ミスフォールディング病 |
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| Research Abstract |
The previous study demonstrated that the engineered β-barrel proteins presenting pseudo-amyloid structures on their surfaces can bind tightly to Alzheimer's amyloid β-peptide (Aβ). In this study, suppression of Aβ toxicity using the engineered β-barrel proteins was evaluated. Moreover, the design strategy using β-barrel proteins was expanded for polyglutamine proteins that relate Huntington's disease.
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