• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2010 Fiscal Year Final Research Report

The development of a new photodynamic therapy-based photo-sensitive drug delivery system

Research Project

  • PDF
Project/Area Number 21710229
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Living organism molecular science
Research InstitutionMukogawa Women's University (2010)
Nara Institute of Science and Technology (2009)

Principal Investigator

AKIYAMA Motofusa  Mukogawa Women's University, 生活環境学部・食物栄養学科, 助手 (90467697)

Project Period (FY) 2009 – 2010
Keywordsドラッグデリバリー / 光線力学療法 / 光増感剤 / 一重項酸素 / フラーレン
Research Abstract

Photodynamic therapy is a next-generation cancer treatment based on cytotoxic singlet oxygen molecules producing photochemical reactions between photoexcited photosensitizers and molecular oxygen. In this study, photodynamic therapy-based drug delivery systems were developed to achieve the photo-inducible controlled release of pharmaceutical compounds from carriers.

  • Research Products

    (12 results)

All 2011 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Formation and regulation of fullerene-incorporation in liposomes under the phase transition temperature.2011

    • Author(s)
      Atsushi Ikeda, Yoshihiko Kawai, Jun-ichi Kikuchi, Motofusa Akiyama, Eiji Nakata, Yoshihiro Uto, Hitoshi Hori.
    • Journal Title

      Organic & Biomolecular Chemistry Vol.9,in press

      Pages: DOI:10.1039/c0ob01030h

    • Peer Reviewed
  • [Journal Article] Water-soluble Inclusion Complexes of [60]Fullerene Derivatives Usingγ-Cyclodextrin.2010

    • Author(s)
      Atsushi Ikeda, Tomoya Genmoto, Naotake Maekubo, Jun-ichi Kikuchi, Motofusa Akiyama, Takayuki Mochizuki, Shuhei Kotani, Toshifumi Konishi.
    • Journal Title

      Chemistry Letters Vol.39

      Pages: 1256-1257

    • Peer Reviewed
  • [Journal Article] Photodynamic Activity of Liposomal Photosensitizers via Energy Transfer from Antenna Molecules to [60]Fullerene.2010

    • Author(s)
      Atsushi Ikeda, Motofusa Akiyama, Takuya Ogawa, Tatsuo Takeya.
    • Journal Title

      ACS Medicinal Chemistry Letters Vol.1

      Pages: 115-119

    • Peer Reviewed
  • [Journal Article] Effect of phase transition temperature of liposomes on preparation of fullerene-encapsulated liposomes by the fullerene-exchange reaction.2010

    • Author(s)
      Atsushi Ikeda, Yoshihiko Kawai, Jun-ichi Kikuchi, Motofusa Akiyama.
    • Journal Title

      Chemical Communications Vol.46

      Pages: 2847-2849

    • Peer Reviewed
  • [Presentation] γ-シクロデキストリンによるフラーレン誘導体の水溶化2011

    • Author(s)
      前久保尚武、秋山元英、池田篤志、菊池純一、小西利史
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2011-03-29
  • [Presentation] 光アンテナ分子-フラーレンを内包したリポソーム型光増感剤のC_<70>による効率化2010

    • Author(s)
      秋山元英、池田篤志、菊池純一、小川拓哉、竹家達夫
    • Organizer
      第25回生体機能関連化学シンポジウム
    • Place of Presentation
      大阪府豊中市
    • Year and Date
      2010-09-25
  • [Presentation] 安定なフラーレン含有リポソーム製剤の新規調製法とその光活性評価2010

    • Author(s)
      池田篤志、秋山元英、河井芳彦、森美由貴、菊池純一、小川拓哉、竹家達夫
    • Organizer
      第59回高分子討論会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2010-09-17
  • [Presentation] カルボシアニン色素を光補集部位として導入したC_<60>含有リポソームの光線力学活性の解析2010

    • Author(s)
      秋山元英、池田篤志、菊池純一、小川拓哉、竹家達夫
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪府東大阪市
    • Year and Date
      2010-03-28
  • [Presentation] 光捕集部位-フラーレンの2元系システムによる光線力学治療薬の開発2009

    • Author(s)
      池田篤志、秋山元英、菊池純一、小川拓哉、竹家達夫
    • Organizer
      第58回高分子討論会
    • Place of Presentation
      熊本県熊本市
    • Year and Date
      2009-09-16
  • [Presentation] カルボシアニン色素を光補集部位として導入したC_<60>内包リポゾームの光線力学活性の解析2009

    • Author(s)
      秋山元英、池田篤志、菊池純一、小川拓哉、竹家達夫
    • Organizer
      第24回生体機能関連化学シンポジウム
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2009-09-14
  • [Remarks] ホームページ等

    • URL

      http://mswebs.naist.jp/LABs/kikuchi/index-j.html

  • [Patent(Industrial Property Rights)] フラーレン誘導体を用いた水溶性光増感性材料2011

    • Inventor(s)
      池田篤志・秋山元英
    • Industrial Property Rights Holder
      国立大学法人奈良先端科学技術大学院大学
    • Industrial Property Number
      2011-048658
    • Acquisition Date
      2011-03-07

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi