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2011 Fiscal Year Final Research Report

Synthetic Approach toward the Structural Elucidation of the Anti-HIV Active Compound Symbiodinolide

Research Project

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Project/Area Number 21710231
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Living organism molecular science
Research InstitutionOkayama University

Principal Investigator

TAKAMURA Hiroyoshi  岡山大学, 大学院・自然科学研究科, 助教 (70422798)

Project Period (FY) 2009 – 2011
Keywords有機合成 / 天然物 / 構造決定
Research Abstract

Organic compounds obtained from the ocean, so-called marine natural products, have received remarkable attention as drug candidate compounds due to their diverse and potent biological activities. Symbiodinolide, the polyol marine natural product with a molecular weight of 2860, has calcium channel opening activity and anti-HIV activity. Therefore, this molecule has been expected to be utilized as the novel medicine. In this research, synthetic study of symbiodinolide toward the structural elucidation has been performed, which has resulted in the synthesis and structural determination of the fragments corresponding to the half of the molecule.

  • Research Products

    (20 results)

All 2012 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (13 results)

  • [Journal Article] Stereocontrolled Synthesis and Structural Confirmation of the C14-C24 Degraded Fragment of Symbiodinolide2010

    • Author(s)
      Takamura Hiroyoshi ; Kadonaga Yuichiro ; Kadota Isao
    • Journal Title

      Uemura Daisuke Tetrahedron

      Volume: 66 Pages: 7569-7576

    • Peer Reviewed
  • [Journal Article] Stereoselective Synthesis of the C14-C24 Degraded Fragment of Symbiodinolide2010

    • Author(s)
      Takamura Hiroyoshi ; Kadonaga Yuichiro ; Kadota Isao
    • Journal Title

      Uemura Daisuke Tetrahedron Lett

      Volume: 51 Pages: 2603-2605

    • Peer Reviewed
  • [Journal Article] Stereoselective Synthesis and Absolute Configuration of the C1'-C25' Fragment of Symbiodinolide2009

    • Author(s)
      Takamura Hiroyoshi ; Murata Takeshi ; Asai Takahiro ; Kadota Isao
    • Journal Title

      Uemura Daisuke J. Org. Chem

      Volume: 74 Pages: 6658-6666

    • Peer Reviewed
  • [Journal Article] Determination of Absolute Configuration of C14-C23 Fragment in Symbiodinolide2009

    • Author(s)
      Han Chunguang ; Yamano Yoshi ; Kita Masaki ; Takamura Hiroyoshi
    • Journal Title

      Uemura Daisuke Tetrahedron Lett

      Volume: 50 Pages: 5280-5282

    • Peer Reviewed
  • [Journal Article] Stereoselective Synthesis and Absolute Configuration of the C33-C42 Fragment of Symbiodinolide2009

    • Author(s)
      Takamura Hiroyoshi ; Kadonaga Yuichiro ; Yamano Yoshi ; Han Chunguang ; Kadota Isao
    • Journal Title

      Uemura Daisuke Tetrahedron

      Volume: 65 Pages: 7449-7456

    • Peer Reviewed
  • [Journal Article] Synthesis and Structural Revision of Symbiodinolide C23-C34 Fragment2009

    • Author(s)
      Murata Takeshi ; Sano Masayuki ; Takamura Hiroyoshi ; Kadota Isao
    • Journal Title

      Uemura Daisuke J. Org. Chem

      Volume: 74 Pages: 4797-4803

    • Peer Reviewed
  • [Journal Article] Synthesis and Structural Determination of the C33-C42 Fragment of Symbiodinolide2009

    • Author(s)
      Takamura Hiroyoshi ; Kadonaga Yuichiro ; Yamano Yoshi ; Han Chunguang ; Aoyama Yoko ; Kadota Isao
    • Journal Title

      Uemura Daisuke Tetrahedron Lett

      Volume: 50 Pages: 863-866

    • Peer Reviewed
  • [Presentation] シンビオジノライドC79-C97フラグメントの合成2012

    • Author(s)
      藤原敬之
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学日吉・矢上キャンパス
    • Year and Date
      20120325-28
  • [Presentation] 構造解明を指向した天然有機化合物の合成研究2011

    • Author(s)
      高村浩由
    • Organizer
      第27回若手化学者のための化学道場(高知2011)
    • Place of Presentation
      かんぽの宿伊野
    • Year and Date
      20110909-10
  • [Presentation] シンビオジノライドC79-C97フラグメントの合成2011

    • Author(s)
      藤原敬之
    • Organizer
      第27回若手化学者のための化学道場(高知2011)
    • Place of Presentation
      かんぽの宿伊野
    • Year and Date
      20110909-10
  • [Presentation] Synthetic Study of the Polyol Marine Natural Product Symbiodinolide2010

    • Author(s)
      Takamura Hiroyoshi
    • Organizer
      PACIFICHEM 2010
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      20101215-20
  • [Presentation] Synthetic Study of the C94-C104 Fragment of Symbiodinolide2010

    • Author(s)
      Tsuda Kosuke
    • Organizer
      PACIFICHEM 2010
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      20101215-20
  • [Presentation] 構造解明を指向したシンビオジノライドの合成研究2010

    • Author(s)
      高村浩由
    • Organizer
      第52回天然有機化合物討論会
    • Place of Presentation
      グランシップ(静岡県コンベンションアーツセンター)
    • Year and Date
      20100929-1001
  • [Presentation] 複雑な構造を有する巨大海洋天然物の合成研究2010

    • Author(s)
      高村浩由
    • Organizer
      第45回天然物化学談話会
    • Place of Presentation
      三谷温泉ホテル明山荘
    • Year and Date
      20100706-08
  • [Presentation] 構造解明を指向したポリオール天然物シンビオジノライドの合成研究2010

    • Author(s)
      高村浩由
    • Organizer
      第97回有機合成シンポジウム
    • Place of Presentation
      慶應義塾大学薬学部(芝共立キャンパス)マルチメディア講堂
    • Year and Date
      20100618-19
  • [Presentation] シンビオジノライドC14-C24フラグメントの立体選択的合成2010

    • Author(s)
      角永悠一郎
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      近畿大学本部キャンパス
    • Year and Date
      20100326-29
  • [Presentation] シンビオジノライドC94-C104フラグメントの合成研究2010

    • Author(s)
      津田浩輔
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      近畿大学本部キャンパス
    • Year and Date
      20100326-29
  • [Presentation] シンビオジノライドC14-C24およびC33-C42フラグメントの立体選択的合成2009

    • Author(s)
      角永悠一郎
    • Organizer
      2009年日本化学会西日本大会
    • Place of Presentation
      愛媛大学城北キャンパス
    • Year and Date
      20091107-08
  • [Presentation] シンビオジノライドC94-C104フラグメントの合成研究2009

    • Author(s)
      津田浩輔
    • Organizer
      第25回若手化学者のための化学道場
    • Place of Presentation
      にぎたつ会館
    • Year and Date
      20090907-08
  • [Presentation] シンビオジノライドC14-C24およびC33-C42フラグメントの立体選択的合成2009

    • Author(s)
      角永悠一郎
    • Organizer
      第44回天然物化学談話会
    • Place of Presentation
      つくばグランドホテル
    • Year and Date
      20090708-10

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Published: 2013-07-31  

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