Central action of lipid metabolism in the brain

2010 Fiscal Year Final Research Report

• Project/Area Number: 21730595
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Experimental psychology
• Research Institution: The University of Tokushima
• Principal Investigator: CHIKAHISA Sachiko The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (00452649)
• Project Period (FY): 2009 – 2010
• Keywords: 生理 / 脂質代謝

Research Abstract

We investigated the contribution of central energy metabolism to higher brain functions, focusing in particular on AMPK and PPARs. PPARs and AMPK are involved in the stimulation of lipid metabolism. We used several drugs that activate PPARs and AMPK. After injection of these drugs, sleep depth and anxiety level were changed. In addition, feeding schedule can alter sleep quality by affecting metabolic function. PPARs and AMPK may play a significant role in the interaction of lipid metabolism and brain function including sleep homeostasis and common neurobehavior.

Research Products

• [Journal Article] Refeeding after a 24-hour fasting deepens NREM sleep in a time-dependent manner (2011)
  • Author(s): Shimizu N, Chikahisa S, Kitaoka K, Seiji N, Sei H.
  • Journal Title: Physiology & Behavior in press
  • Peer Reviewed
• [Journal Article] Disturbance of rapid eye movement sleep in senescence-accelerated mouse prone/8 mice is improved by retinoic acid receptor agonist Am80 (Tamibarotene). (2010)
  • Author(s): Kitaoka K, Sano A, Chikahisa S, Yoshizaki K, Sei H.
  • Journal Title: Neuroscience 167 Pages: 573-582
  • Peer Reviewed
• [Journal Article] Central AMPK contributes to sleep homeostasis in mice. (2009)
  • Author(s): Chikahisa S, Fujiki N, Kitaoka K, Shimizu N, Sei H.
  • Journal Title: Neuropharmacology 57 Pages: 369-374
  • Peer Reviewed
• [Presentation] Hypothalamic AMPK contributes to homeostatic sleep regulation (2010)
  • Author(s): Chikahisa S, Kitaoka K, Shimizu N, Sei H
  • Organizer: Neuroscience 2010
  • Place of Presentation: San Diego, USA
  • Year and Date: 20101113-20101117
• [Presentation] Sleep regulation in PPARα knockout mice (2010)
  • Author(s): Shimizu N, Chikahisa S, Kitaoka K, Sei H
  • Organizer: Neuroscience 2010
  • Place of Presentation: San Diego, USA
  • Year and Date: 20101113-20101117
• [Presentation] 中枢脂質代謝と睡眠ホメオスタシス (2010)
  • Author(s): 近久幸子, 勢井宏義
  • Organizer: 日本睡眠学会第35回定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 20100701-20100702
• [Presentation] 睡眠のホメオスタシスと代謝機構 (2009)
  • Author(s): 勢井宏義, 近久幸子, 北岡和義
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 20091209-20091212
• [Presentation] Refeeding at light-onset after 24h fasting enhances EEG delta-power in NREM sleep in mice. (2009)
  • Author(s): Shimizu N, Chikahisa S, Oura M, Sei H
  • Organizer: The 6th Congress of Asian Sleep Research Society・The 34th Annual Meeting of Japanese Society of Sleep Research
  • Place of Presentation: Osaka, Japan
  • Year and Date: 20091024-20091027
• [Presentation] Role of central AMPK in sleep homeostasis (2009)
  • Author(s): Sei H, Chikahisa S, Shimizu N
  • Organizer: The 6th Congress of Asian Sleep Research Society・The 34th Annual Meeting of Japanese Society of Sleep Research
  • Place of Presentation: Osaka, Japan
  • Year and Date: 20091024-20091027
• [Presentation] Central AMPK contributes to sleep regulation (2009)
  • Author(s): Chikahisa S, Shimizu N, Kitaoka K, Fujiki N, Sei H
  • Organizer: 36th International Union of Physiological Sciences
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20090701-20090801
• [Presentation] EEG delta power in NREM sleep is enhanced by refeeding after 24-hr fasting in time-dependent manner (2009)
  • Author(s): Shimizu N, Oura M, Chikahisa S, Sei H
  • Organizer: 36th International Union of Physiological Sciences
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20090701-20090801