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2010 Fiscal Year Final Research Report

Development of synthesis of chiral nitrogen-containing building blocks

Research Project

  • PDF
Project/Area Number 21750048
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Organic chemistry
Research InstitutionKyushu University

Principal Investigator

UCHIDA Tatsuya  Kyushu University, 大学院・理学研究院, 助教 (50380564)

Project Period (FY) 2009 – 2010
Keywords不斉合成 / キラルビルディングブロック / 含窒素化合物 / アジド / 低環境負荷
Research Abstract

We found that Ru(CO)-salen complex is a potent efficient catalyst for the aziridination of vinyl ketones with N-(2-trimethylsilyl)ethanesulfonyl azide as a nitrene precursor. The reaction generated with almost enantiomerically pure aziridino ketones. Furthermore, we could demonstrate that enantioselective short step formal synthesis of (+)-PD 128907 which is a potent dopamine D3 receptor agonist.

  • Research Products

    (11 results)

All 2011 2010 2009 2006 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] Photopromoted Ru-Catalyzed Asymmetric Aerobic Sulfide Oxidation and Epoxidation Using Water as a Proton Transfer Mediator.2010

    • Author(s)
      Tanaka, H., Nishikawa, H., Uchida, T., Katsuki, T.
    • Journal Title

      J.Am.Chem.Soc. 132(34)

      Pages: 12034-12041

    • Peer Reviewed
  • [Journal Article] Ru(PPh3)(OH)-salen complex : a Designer Catalyst for Chemoselective Aerobic Oxidation of Primary Alcohols.2009

    • Author(s)
      Mizoguchi, H., Uchida, T., Katsuki, T.
    • Journal Title

      Tetrahedron Lett. 50(26)

      Pages: 3432-3435

    • Peer Reviewed
  • [Journal Article] Photopromoted Construction of a New Type of Chiral Bidentate NHC Ligands : Copper-Catalyzed Asymmetric Conjugate Alkylation.2006

    • Author(s)
      Uchida, T., Katsuki, T.
    • Journal Title

      Tetrahedron Lett. 50(33)

      Pages: 4741-4743

    • Peer Reviewed
  • [Presentation] 新規ルテニウムサレン錯体の合成と光非照射下での酸素酸化:第二級アルコールの速度論的光学分割2011

    • Author(s)
      溝口大昂、内田竜也、香月勗
    • Organizer
      第91回日本化学会春季年会
    • Place of Presentation
      横浜市・神奈川大学
    • Year and Date
      2011-03-28
  • [Presentation] 不斉アジリジン化を鍵反応とするドーパミンD3受容体アゴニスト(+)-PD128907の不斉形式全合成2011

    • Author(s)
      福永恭章、内田竜也、香月勗
    • Organizer
      第91回日本化学会春季年会
    • Place of Presentation
      横浜市・神奈川大学
    • Year and Date
      2011-03-27
  • [Presentation] ルテニウム(CO)サレン触媒を用いたビニルケトンの不斉アジリジン化:光学的に純粋なアジリジノケトンの合成2010

    • Author(s)
      福永恭章、内田竜也、香月勗
    • Organizer
      第90回日本化学会春季年会
    • Place of Presentation
      大阪市・近畿大学
    • Year and Date
      2010-03-28
  • [Presentation] ルテニウム-サレン錯体を触媒とする不斉酸素酸化:オレフィンのエポキシ化2010

    • Author(s)
      田中春菜、内田竜也、香月勗
    • Organizer
      第90回日本化学会春季年会
    • Place of Presentation
      大阪市・近畿大学
    • Year and Date
      2010-03-28
  • [Presentation] 新規光学活性二座NHC-銅錯体を用いた不斉共役付加反応2010

    • Author(s)
      内田竜也、香月勗
    • Organizer
      第90回日本化学会春季年会
    • Place of Presentation
      大阪市・近畿大学
    • Year and Date
      2010-03-28
  • [Presentation] Cu-Catalyzed Asymmetric Conjugate Addition of Dialkylzinc to Acyclic Enones Using a New Type of Chiral Bidentate NHC Ligands2009

    • Author(s)
      Tatsuya Uchida, Tsutomu Katsuki
    • Organizer
      IKCOC-11
    • Place of Presentation
      京都市・リーガロイヤルホテル
    • Year and Date
      2009-11-11
  • [Presentation] Design of New Ru(PPh3)(OH)-salen complex : Chemoselective Aerobic Oxidation of Primary Alcohols2009

    • Author(s)
      Hirotaka Mizoguchi, Tatsuya Uchida, Kohichi Ishida, Tsutomu Katsuki
    • Organizer
      IKCOC-11
    • Place of Presentation
      京都市・リーガロイヤルホテル
    • Year and Date
      2009-11-11
  • [Remarks] ホームページ等

    • URL

      http://www.scc.kyushu-u.ac.jp/Yuhan/Katsuki_Lab/Publication_List.html

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Published: 2012-02-13   Modified: 2016-04-21  

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