2010 Fiscal Year Final Research Report
Development of synthesis of chiral nitrogen-containing building blocks
| Project/Area Number |
21750048
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Organic chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
UCHIDA Tatsuya Kyushu University, 大学院・理学研究院, 助教 (50380564)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 不斉合成 / キラルビルディングブロック / 含窒素化合物 / アジド / 低環境負荷 |
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| Research Abstract |
We found that Ru(CO)-salen complex is a potent efficient catalyst for the aziridination of vinyl ketones with N-(2-trimethylsilyl)ethanesulfonyl azide as a nitrene precursor. The reaction generated with almost enantiomerically pure aziridino ketones. Furthermore, we could demonstrate that enantioselective short step formal synthesis of (+)-PD 128907 which is a potent dopamine D3 receptor agonist.
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