2010 Fiscal Year Final Research Report
Gene sensors based on "signal-on"-typed electrochemical sensingmethods
| Project/Area Number |
21750085
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Analytical chemistry
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
AOKI Hiroshi National Institute of Advanced Industrial Science and Technology, 環境管理技術研究部門, 主任研究員 (00392580)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 化学センサー / 電気化学 / バイオセンサ |
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| Research Abstract |
To promote high-sensitive gene detection methods with simplicity and rapidity, a novel "signal-on"-typed gene probe was developed based on dissociation of a redox complex triggered by DNA recognition. The probe enabled simple DNA detection for non-labeled DNAs with 5-fold increase in observed redox current. Moreover, gene sensing devices were developed to simultaneously detect multiple DNAs with simplicity, rapidity, and sequence-specificity.
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[Remarks] 受賞(計4件)
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[Remarks] 優秀ポスター賞、青木寛、北島明子、鳥村政基:簡便・迅速な遺伝子検出法の開発とデバイス化、産総研・産技連LS-BT合同研究発表会、2010年.
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[Remarks] ハイライト講演、H.Aoki, A.Kitajima, H.Tao, Label-free, reagent-free, and "signal-on" DNA detection based on supramolecular electrochemistry, Pacifichem2010、2010年.
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[Remarks] 奨励賞、青木寛、電気化学的遺伝子検出法の開発と迅速遺伝子診断技術の開発、日本分析化学会、2009年.
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[Remarks] 優秀ポスター賞、青木寛、北島明子、田尾博明、超分子電気化学に基づく遺伝子検出法、東京コンファレンス2009年.
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