2010 Fiscal Year Final Research Report
Development of Asymmetric Organo Acid Catalyst Possessing Perfluorophenyl Group for Allylation Reaction
| Project/Area Number |
21750087
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
MOMIYAMA Norie Tohoku University, 大学院・理学研究科, 助教 (80447127)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 不斉合成 / 反応 |
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| Research Abstract |
The present study was conducted based on the development of chiral organo acid catalyst for enantioselective synthesis of homoallylamines. We successfully synthesized chiral phosphoric acid catalyst possessing pentafluorophenyl group for highly enantioselective Hosomi-Sakurai allylation reaction of imines with allyltrimethylsilanes. When the reaction was conducted with 3,5-di-tert-butyl benzoyl mine in the presence of 20 mol% chiral binaphtol derived phosphoric acid and 80mol% biphenol derived phosphoric acid, the homoallylamines were obtained in good yields with high enantioselectivites (90-99% ee).
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