2010 Fiscal Year Final Research Report
Development of Highly Selective Addition Reaction with Metal Ate Salt Catalysts
| Project/Area Number |
21750094
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
HATANO Manabu Nagoya University, 工学研究科, 講師 (20362270)
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| Project Period (FY) |
2009 – 2010
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| Keywords | アート錯体 / 有機金属反応剤 / 触媒反応 / カルボニル化合物 / ケトン / アルコール |
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| Research Abstract |
Addition of organometallic reagents to carbonyl compounds is one of the most important reactions in organic chemistry. In this study, we developed the activation of not only less reactive ketones but also organometallic reagents using highly active metal ate salt catalysts. Based on the activation of carbon-metal bond and the subsequent carbon-carbon bond forming reactions, we developed the highly efficient, practical tertiary alchol synthesis. Moreover, catalytic asymmetric tertiary alchol synthesis was established in the presence of chiral Zn(II)-ate catalysts.
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