2010 Fiscal Year Final Research Report
Development and Application of Novel Chiral Ionic Bronsted Acid
| Project/Area Number |
21750095
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
URAGUCHI Daisuke Nagoya University, 工学研究科, 講師 (70426328)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 合成有機化学 / 有機触媒 |
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| Research Abstract |
A series of novel chiral ionic Bronsted acids, P-spiro chiral tetraaminophosphonium barfate, have been developed. These chiral salts were found to be an effective catalyst for hetero-Michael addition to nitroolefins with highly enantioselective manner, which is regarded as one of the challenging transformations. The products of these reactions are useful chiral intermediate of biologically relevant molecules. Further, the acidity of the salt was successfully enhanced trough the appropriate structural modification.
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