2010 Fiscal Year Final Research Report
Efficient Synthesis of Optically Active Halogenated Compounds with ?-Halocarbonyl Compounds
| Project/Area Number |
21750096
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Toyohashi University of Technology |
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Principal Investigator |
SHIBATOMI Kazutaka Toyohashi University of Technology, 大学院・工学研究科, 助教 (00378259)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 不斉合成・反応 |
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| Research Abstract |
Fluorinated organic molecules are known to be quite important in the synthesis of drugs and their candidates. Efficient synthetic methods for these compounds, especially having a fluorinated chiral carbon center, are strongly required. Here, we succeeded in asymmetric fluorination of alfa-chloro ketoester, and also succeeded in asymmetric Diels-Alder reaction of alfa-fluoro enone. These reactions afforded some new class of chiral fluorinated compounds with high optical purity. These compounds are expected to be useful building blocks for drug design.
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