2010 Fiscal Year Final Research Report
Development of Catalytic Behavior of Borderline Metal complexes and Its Applications for Organic Synthesis
| Project/Area Number |
21750104
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
KOMEYAMA Kimihiro Hiroshima University, 大学院・工学研究院, 助教 (80432681)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 鉄触媒 / ビスマス触媒 / ヒドロアミノ化反応 / ヒドロアリール化反 / タンデム反応 / 複素環状化合物 / 芳香族縮環化合物 |
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| Research Abstract |
Borderline metal-catalyzed cycloisomerization of amino-allenes were investigated. In the reaction, we found that bismuth(III) triflate were more effective catalyst to proceed the reaction than other transition metal catalysts. The bismuth-catalyzed hydroamination can be applied to tandem ene-hydroamination of amino-allenes and amino-olefins with activated olefins and benzyl alcohols to provide multi-substituted N-heterocycles in good yields. In addition, we developed a cationic iron-catalyzed intramolecular hydroarylation of alkynes. In this reaction, the cationic iron catalyst promoted the addition of electron deficient arenes possessing strong electron-withdrawing group to alkynes, efficiently. This reactivity was very unique in comparison with other traditional catalysts for the similar hydroamination.
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