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2010 Fiscal Year Final Research Report

Development of New Cascade Type Reactions Catalyzed by Metal Hydrides

Research Project

  • PDF
Project/Area Number 21750106
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Synthetic chemistry
Research InstitutionOsaka Prefecture University

Principal Investigator

FUKUYAMA Takahide  Osaka Prefecture University, 理学系研究科, 准教授 (60332962)

Project Period (FY) 2009 – 2010
Keywords遷移金属ヒドリド / 連続結合形成 / 触媒反応 / ヒドロメタル化
Research Abstract

This research aimed at development of new catalytic reactions in which metal hydride species play a key role. The reaction of benzylic alcohols with α,β-unsaturated aldehydes in the presence of ruthenium-hydride gave α-hydroxymethyl ketones. α-Hydroxymethyl ketones underwent retro-aldol reaction in fluorous-organic hybrid solvent, F-626. One-pot procedure for the synthesis of ketones has also been achieved by the consecutive ruthenium hydride-catalyzed reaction and the thermal retro-aldol reaction. RuHCl(CO)(PPh_3)_3 effectivly catalyzed intramolecular Tishchenko reaction. The reaction of enones with dialdehydes gave keto lactons in good yields via sequential C-C and CO bond formation. Boronic acids react with aldehydes in the presence of RuHCl(CO)(PPh_3)_3 to give ketones. Ir catalyzed decarbonylation took place to give internal olefins, where addition of KI dramatically accelerated the decarbonylation reactions. Ir-H species formed in situ catalyzed isomerization of olefins.

  • Research Products

    (12 results)

All 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] Et_2MeN・HI-Catalyzed Reaction of Arylboronic Acids with 2-Acyl-2,3-dihydro-4H-pyrans Leading to 2-Aryl-Tetrahydro-cyclopenta [1,3,2]dioxaboroles2011

    • Author(s)
      T.Fukuyama, T.Okamura, I.Ryu
    • Journal Title

      Synthesis

      Pages: 1537-1540

  • [Journal Article] Efficient Iridium-Catalyzed Decarbonylation Reaction of Aliphatic Carboxylic Acids Leading to Internal or Terminal Alkenes2011

    • Author(s)
      S.Maetani, T.Fukuyama, N.Suzuki, D.Ishihara, I.Ryu
    • Journal Title

      Organometallics 30巻

      Pages: 1389-1394

  • [Journal Article] マルチタスク触媒:ルテニウムヒドリドによる原子効率型結合形成反応2010

    • Author(s)
      福山高英、大村倉平、柳日馨
    • Journal Title

      有機合成化学協会誌 68巻

      Pages: 649-658

    • Peer Reviewed
  • [Journal Article] Synthesis of 2-Hydroxymethyl Ketones by Ruthenium Hydride-Catalyzed Cross-Coupling Reaction ofα,β-Unsaturated Aldehydes with Primary Alcohols2010

    • Author(s)
      A.Denichoux, T.Fukuvama, T.Doi, J.Horiguchi, I.Ryu
    • Journal Title

      Org.Lett. 12巻

      Pages: 1-3

  • [Journal Article] Thermal Retro-Aldol Reaction Using a Fluorous Ether F-626 as a Reaction Medium2010

    • Author(s)
      T.Fukuvama, T.Kawamoto, T.Okamura, A.Denichoux, I.Ryu
    • Journal Title

      Synlett

      Pages: 2193-2196

  • [Journal Article] Synthesis of Functionalized Resorcinols by Rhodium-Catalyzed [5+1] Cycloaddition Reaction of 3-Acyloxy-1,4-Enynes with CO2010

    • Author(s)
      C.Brancour, T.Fukuyama, Y.Ohta, I.Ryu, A.-L.Dhimane, L.Fensterbank, M.Malacria
    • Journal Title

      Chem.Commun. 46巻

      Pages: 5470-5472

  • [Journal Article] Hydroruthenation Triggered Catalytic Conversion of Dialdehydes and Keto Aldehydes to Lactones2009

    • Author(s)
      S.Omura, T.Fukuvama, Y.Murakami, H.Okamoto, I.Ryu
    • Journal Title

      Chem.Commun.

      Pages: 6741-6743

  • [Presentation] Decarbonylation Reaction of Aliphatic Carboxylic Acids Leading to Olefins2010

    • Author(s)
      S.Maetani, T.Fukuvama, I.Ryu, H.Tahara, N.Suzuki, D.Ishihara, D.Iron-Catalyzed
    • Organizer
      第57回有機金属化学討論会
    • Place of Presentation
      中央大学
    • Year and Date
      2010-09-16
  • [Presentation] Rhodium-Catalyzed [4+1] Type Carbonylative Cycloaddition of 1,4-Enyne Esters Involving 1,3-Acyloxy Migration2010

    • Author(s)
      T.Fukuyama, Y.Ohta, I.Ryu
    • Organizer
      第57回有機金属化学討論会
    • Place of Presentation
      中央大学
    • Year and Date
      2010-09-16
  • [Presentation] ルテニウム触媒を用いた新合成反応の開発2009

    • Author(s)
      福山高英
    • Organizer
      第36回有機反応懇談会
    • Place of Presentation
      関西学院大学
    • Year and Date
      2009-08-03
  • [Presentation] Ruthenium Hydride-Catalyzed Lactonization of Dialdehydes and Keto Aldehydes2009

    • Author(s)
      T.Fukuvama, S.Omura, H.Okamoto, Y.Murakami, I.Ryu
    • Organizer
      OMCOS 15
    • Place of Presentation
      グラスゴー,英国
    • Year and Date
      2009-07-29
  • [Presentation] New Strategy Towards the Synthesis of Resorcinol Derivatives by Rhodium-Catalyzed Carbonylation of 1,4-Enynes2009

    • Author(s)
      C.Brancour, T.Fukuyama, Y.Ota, I.Ryu, A.-L.Dhimane, L.Fensterbank, M.Malacria
    • Organizer
      OMCOS 15
    • Place of Presentation
      グラスゴー,英国
    • Year and Date
      2009-07-29

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Published: 2012-02-13   Modified: 2016-04-21  

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