2010 Fiscal Year Final Research Report
Synthesis and properties of boron containing nucleobases analogues
| Project/Area Number |
21750134
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional materials chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ITO Hiroshi The University of Tokyo, 大学院・理学研究科, 特任講師 (90506734)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 分子認識 / 人工核酸塩基 / ヘテロ環 / 含ホウ素化合物 / 蛍光プローブ |
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| Research Abstract |
As isoelectronic analogs of nucleobases, a series of BN-substituted nucleobases were synthesized and fully characterized. The crystallographic and spectroscopic analyses of B(6)-substituted 5-aza-6-borauracils (UBNs) and -thymines (TBNs) revealed that the framework and hydrogen-bonding pattern of the nucleobase analogues were similar to those of the original nucleobase. These "BN-nucleobases" are expected to be applied for novel photo-probes because they showed particular luminescence depended on the substitute on the boron atom.
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