2010 Fiscal Year Final Research Report
Novel ion channel analogues by peptide nanotubes containing fluorinated amino acids
| Project/Area Number |
21750137
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional materials chemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
ISHIDA Yasuhiro The Institute of Physical and Chemical Research, 生体模倣材料研究チーム, チームリーダー (20343113)
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| Project Period (FY) |
2009 – 2010
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| Keywords | βアミノ酸 / フッ素化アミノ酸 / ペプチド / 自己組織化 / 水素結合 / 大環状化合物 / らせん / ナノチューブ |
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| Research Abstract |
Facile control of the secondary structure of beta-peptides was attempted, by introducing fluorinated beta-amino acids in the peptides. Our achievements include (1) large-scale asymmetric synthesis of enantiopure fluorinated beta-amino acids, (2) establishing the peptide elongation of fluorinated beta-amino acids, and (3) application of fluorinated beta-amino acids to peptide engineering.
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