2010 Fiscal Year Final Research Report
Development of time-resolved circular dichroism measurement and its application to the detection of conformational dynamics in DNA-ligand complex
| Project/Area Number |
21750164
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Tohoku University |
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Principal Investigator |
ARAKI Yasuyuki 東北大学, 多元物質科学研究所, 助教 (80361179)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 生体機能関連化学 |
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| Research Abstract |
We aimed to develop the time-resolved circular dichroism measurement for the purpose of the detection of the dynamic behavior of this DNA-drug interactions, focusing on an entire chirality occurring as a result of DNA-drug interaction. We have successfully developed it and detected the dynamic behavior of DNA-drug interactions caused by the laser-induced conformational change of DNA-drug complexes.
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[Journal Article] Multiple photosynthetic reaction centres composed of supramolecular assemblies of zinc porphyrin dendrimers with a fullerene acceptor2011
Author(s)
Fukuzumi, S., Saito, K., Ohkubo, K., Kashiwagi, Y., Araki, Y., 他6名
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Journal Title
Chem. Commun.
Volume: 47
Pages: 7980-7982
Peer Reviewed
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