2010 Fiscal Year Final Research Report
Development of inhibitors based on short helical peptides for protein-protein interactions
| Project/Area Number |
21750167
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | University of Toyama |
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Principal Investigator |
FUJIMOTO Kazuhisa University of Toyama, 大学院・医学薬学研究部, 助教 (40334718)
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| Project Period (FY) |
2009 – 2010
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| Keywords | α-ヘリックス / タンパク間相互作用 / 阻害剤 / 生体高分子 |
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| Research Abstract |
I explored the effect of α-helical stabilization upon the binding of short peptides to DNAs. When a cross-linked peptide based on the homeodomain of transcription factor was titrated with a target DNA duplex, its dissociation constant (Kd) was calculated to be ca. 0.5 nM. This value was the double-digit smaller than that of the corresponding non-cross-linked peptide. The cross-linked peptide showed high substrate specificity for DNAs at the same level as the original DNA-binding protein.
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[Journal Article] Photophysical Properties of 1,3,6,8-Tetrakis(arylethynyl)pyrenes with Donor or Acceptor Substituents: Their Fluorescence Solvatochromism and Lightfastness2009
Author(s)
Kazuhisa Fujimoto, Hisao Shimizu, Masaru Furusyo, Seiji Akiyama, Mio Ishida, Utako Furukawa, Toshiaki Yokoo, Masahiko Inouye
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Journal Title
Tetrahedron 65巻
Pages: 9357-9361
Peer Reviewed
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