2010 Fiscal Year Final Research Report
Creation of New Artificial Metalloenzyme by using the intrinsic chemical reactivity
| Project/Area Number |
21750169
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Osaka University |
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Principal Investigator |
FUJIEDA Nobutaka Osaka University, 工学研究科, 助教 (00452318)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 酸素活性化 / 銅タンパク質 / 過酸化水素 / 水酸化反応 / 交差反応性 |
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| Research Abstract |
We have isolated one of the monomeric subunits as well as the hexameric assembly of swimming crab Portunus trituberculatus and attempted to convert them to monooxygenase by applying the above-mentioned sysetm. We also tried to develop a metallo-β-lactamase to construct a new artificial dinuclear metalloenzymes as a metal-binding platform.
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[Journal Article]2011
Author(s)
Nobutaka Fujieda, Takuya Ikeda, Michiaki Murata, Sachiko Yanagisawa, Shigetoshi Aono, Kei Ohkubo, Satoshi Nagao, Takashi Ogura, Shun Hirota ,Shunichi Fukuzumi, Yukihiro Nakamura, Yoji Hata, Shinobu Itoh
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Journal Title
J.Am.Chem.Soc. 133(5)
Pages: 1180-1183
Peer Reviewed
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