2010 Fiscal Year Final Research Report
Analysis of the basement membrane function and application to the artificial basement membrane
| Project/Area Number |
21750174
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
HOZUMI Kentaro Tokyo University of Pharmacy and Life Science, 薬学部, 助教 (10453804)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ラミニン / 基底膜 / 細胞接着 / 細胞外マトリックス / インテグリン / 細胞生物学 |
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| Research Abstract |
Molecular dissection of laminin by synthetic peptides was tested and found that biological activities of laminin could analyze and mimic using laminin active peptides. The laminin derived mixed peptides-polysaccharides exhibited many biological activities and these activities can control by changing the biological and physical properties of peptides-polysaccharides. Combinations of the peptides and the polysaccharides provide unique peptide-matrices with different biological activities, suggesting that these constructs are useful for cell type specific biomaterials.
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