2010 Fiscal Year Final Research Report
Development of novel Ends-Quencher-Free molecular beacon for DNA sequence analysis
| Project/Area Number |
21750176
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Chemistry related to living body
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
SAITO Yoshio Nihon University, 工学部, 准教授 (40385985)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | DNA / 蛍光プローブ |
|---|
| Research Abstract |
We synthesized various substituted fluorescent deoxyadenosine derivatives. Among them cyano-substituted deoxyguanosine analog showed a remarkable solvatochromicity. Such environmentally sensitive solvatochromic fluorescent adenosine analog may be useful for sequence specific DNA detection with high efficiency.
|
