2010 Fiscal Year Final Research Report
Development of anticancer platinum complexes that recognize a specific region of nucleic acid.
| Project/Area Number |
21750177
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
KOMEDA Seiji Suzuka University of Medical Science, 薬学部, 助教 (60425056)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 白金錯体 / 制がん剤 / X線結晶解析 / シスプラチン / DNA |
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| Research Abstract |
We have synthesized a series of tetrazolate-bridged dinuclear Pt(II) complexes as a new class, in order to develop next-generation platinum-based anticancer drugs which are effective against cancers that are typically resistant to chemotherapy. In vivo antitumor efficacy of one of the complexes was evaluated on xenografted tumors of H460 non-small cell lung cancer and PANC-1 pancreatic cancer. The complex exhibited markedly high antitumor efficacy against pancreatic cancer. The tetrazolate-bridged complexes resulted to interact with DNA in a manner different from that of clinical platinum-based drugs.
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[Journal Article] The phosphate clamp: a small and independent motif for nucleic acid backbone recognition.2011
Author(s)
Komeda, S., Moulaei, T., Chikuma, M., Odani, A., Kipping, R., Farrell, N.P., Williams, L.D.
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Journal Title
Nucleic Acids Res. 39
Pages: 325-336
Peer Reviewed
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[Journal Article] A new class of rhodamine luminophores : design, syntheses and aggregation-induced emission enhancement.2010
Author(s)
Kamino, S., Horio, Y., Komeda, S., Minoura, K., Ichikawa, H., Horigome, J., Tatsumi, A., Kaji, S., Yamaguchi, T., Usami, Y., Hirota, S., Enomoto, S., Fujita Y.
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Journal Title
Chem.Commun. 46
Pages: 9013-9015
Peer Reviewed
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[Journal Article] Characteristic effect of an anticancer dinuclear platinum(II) complex on the higher-order structure of DNA.2010
Author(s)
Kida, N., Katsuda, Y., Yoshikawa, Y., Komeda, S., Sato, T., Saito, Y., Chikuma, M., Suzuki, M., Imanaka, T., Yoshikawa, K.
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Journal Title
J.Biol.Inorg.Chem. 15
Pages: 701-707
Peer Reviewed
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[Presentation] 核酸の特定部位を認識する制がん白金錯体2009
Author(s)
米田誠治, Nicholas P.Farrell, Loren D.Willialns, 小谷明, 千熊正彦
Organizer
第24回生体機能関連化学部会シンポジウム
Place of Presentation
九州大学医学部百周年会館(福岡市)
Year and Date
2009-09-15
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[Presentation] Design, structure-activity relationships and x-ray co-crystallography of anticancer-active polynyclear platinum(II) complexes2009
Author(s)
Komeda, S., Odani, A., Chikuma, M., Farrell, N.P., Williams, L.D.
Organizer
14th International Conference on Biological Inorganic Chemistry
Place of Presentation
名古屋国際会議場(名古屋市)
Year and Date
2009-07-27
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[Book]2010
Author(s)
腫瘍薬学(共著)
Total Pages
177-182
Publisher
南山堂
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