Development of multiscale analysis method for medical applications using microbubbles

2010 Fiscal Year Final Research Report

• Project/Area Number: 21760120
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Fluid engineering
• Research Institution: The University of Tokyo
• Principal Investigator: SUGIYAMA Kazuyasu The University of Tokyo, 大学院・工学系研究科, 特任准教授 (50466786)
• Project Period (FY): 2009 – 2010
• Keywords: 数値流体力学

Research Abstract

In consideration of lubricated, acoustic and thermal properties in microbubbly fluid systems, efficient numerical solvers for the flow motion have been equipped. A numerical algorithm was developed to capture the flexibility in the biomaterial/membrane. For the microbubble dynamics, insight into several behaviors such as a lift force in a shear flow, a deformation mode in an acoustic field and a heat source due to the volume oscillation was gained. The simulation method was applied to predicting a microbubble heat enhancement in an ultrasound field, and confirmed to qualitatively reproduce the measured relation between the heated region and the void fraction.

Research Products

• [Journal Article] A full Eulerian finite difference approach for solving fluid-structure coupling problems (2011)
  • Author(s): Sugiyama, K., Ii, S., Takeuchi, S., Takagi, S., Matsumoto, Y.
  • Journal Title: Journal of Computational Physics Vol.230 Pages: 596-627
  • Peer Reviewed
• [Journal Article] Particle-in-cell method for fluid-structure interaction simulations of neo-Hookean tube flows (2011)
  • Author(s): Sugiyama, K., Nagano, N., Takeuchi, S., Ii, S., Takagi, S., Matsumoto, Y.
  • Journal Title: Theoretical and Applied Mechanics Japan Vol.59 Pages: 245-256
  • Peer Reviewed
• [Journal Article] An implicit full Eulerian method for the fluid-structure interaction problem (2011)
  • Author(s): Ii, S., Sugiyama, K., Takeuchi, S., Takagi, S., Matsumoto, Y.
  • Journal Title: International Journal for Numerical Methods in Fluids Vol.65 Pages: 150-165
  • Peer Reviewed
• [Journal Article] Numerical study on the shape oscillation of an encapsulated microbubble in ultrasound field (2011)
  • Author(s): Liu, Y.-Q., Sugiyama, K., Takagi, S., Matsumoto, Y.
  • Journal Title: Physics of Fluids Vol.23 Pages: 041904
  • Peer Reviewed
• [Journal Article] Theoretical study on acoustic dynamics of circular liquid-gas micro-meniscus (2010)
  • Author(s): Sugiyama, K., Rathgen, H.
  • Journal Title: Theoretical and Applied Mechanics Japan Vol.58 Pages: 251-260
  • Peer Reviewed
• [Journal Article] Full Eulerian simulations of biconcave neo-Hookean particles in a Poiseuille flow (2010)
  • Author(s): Sugiyama, K., Ii, S., Takeuchi, S., Takagi, S., Matsumoto, Y.
  • Journal Title: Computational Mechanics Vol.46 Pages: 147-157
  • Peer Reviewed
• [Journal Article] Full-Eulerian finite-difference simulation of fluid flow in hyperelastic wavy channel (2010)
  • Author(s): Nagano, N., Sugiyama, K., Takeuchi, S., Ii, S., Takagi, S., Matsumoto, Y.
  • Journal Title: Journal of Fluid Science and Technology Vol.5 Pages: 475-490
  • Peer Reviewed
• [Journal Article] 一様流中の円柱周りの減圧挙動に対する流れの剥離の影響 (2009)
  • Author(s): 杉山和靖
  • Journal Title: 日本機械学会論文集B 65巻 Pages: 2361-2368
  • Peer Reviewed
• [Presentation] 擬似圧縮性法に基づく完全オイラー型流体構造連成解析 (2011)
  • Author(s): 杉山和靖, 伊井仁志, 高木周, 松本洋一郎
  • Organizer: 生体力学シミュレーション研究
  • Place of Presentation: 理化学研究所,埼玉
  • Year and Date: 2011-03-09
• [Presentation] 固定メッシュ法に基づく流体構造連成シミュレーション (2010)
  • Author(s): 杉山和靖, 伊井仁志, 竹内伸太郎, 高木周, 松本洋一郎
  • Organizer: 第24回数値流体力学シンポジウム
  • Place of Presentation: 慶應義塾大学日吉キャンパス,神奈川
  • Year and Date: 2010-12-20
• [Presentation] Deformation-induced lateral migration of a bubble slowly rising near a vertical plane wall (2010)
  • Author(s): Sugiyama, K., Takemura, F.
  • Organizer: 63rd Annual Meeting of the APS Division of Fluid Dynamics
  • Place of Presentation: Long Beach, California, USA.
  • Year and Date: 2010-11-23
• [Presentation] Deformation-induced lift force on a bubble slowly rising near a vertical plane wall (2010)
  • Author(s): Sugiyama, K., Takemura, F.
  • Organizer: 8th Japan-UK Seminar on Multiphase Flows
  • Place of Presentation: 小樽,北海道
  • Year and Date: 2010-09-14
• [Presentation] 音場中の気液マイクロメニスカス界面の変形 (2010)
  • Author(s): 杉山和靖
  • Organizer: 日本流体力学会年会2010
  • Place of Presentation: 北海道大学,北海道
  • Year and Date: 2010-09-10
• [Presentation] 壁面に沿う流れにおける超弾性体のオイラー型シミュレーション (2010)
  • Author(s): 杉山和靖, 伊井仁志, 竹内伸太郎, 高木周, 松本洋一郎
  • Organizer: 日本機械学会年次大会
  • Place of Presentation: 名古屋工業大学,愛知
  • Year and Date: 2010-09-08
• [Presentation] 固定メッシュ法に基づくネオフック体管内流の流体構造連成シミュレーション (2010)
  • Author(s): 杉山和靖, 長野直大, 竹内伸太郎, 伊井仁志, 高木周, 松本洋一郎
  • Organizer: 第59回理論応用力学講演会
  • Place of Presentation: 日本学術会議,東京
  • Year and Date: 2010-06-10
• [Presentation] A full Eulerian finite difference approach for fluid-structure coupling problems (2010)
  • Author(s): Sugiyama, K., Ii, S., Takeuchi, S., Takagi, S., Matsumoto, Y.
  • Organizer: International Conference on Multiphase Flow
  • Place of Presentation: Tampa Bay, Florida, USA.
  • Year and Date: 2010-06-04
• [Presentation] 現配置参照型流体構造連成オイラー解析法 (2009)
  • Author(s): 杉山和靖, 竹内伸太郎, 伊井仁志, 高木周, 松本洋一郎
  • Organizer: 第23回数値流体力学シンポジウム
  • Place of Presentation: 東北大学,宮城
  • Year and Date: 2009-12-17
• [Presentation] 鉛直平板付近を上昇する変形気泡の揚力に対する潤滑効果 (2009)
  • Author(s): 杉山和靖, 竹村文男
  • Organizer: 日本流体力学会年会2009
  • Place of Presentation: 東洋大学,東京
  • Year and Date: 2009-09-02