2011 Fiscal Year Final Research Report
Highly functionalized drug-eluting stent systems controlled by combining polymers with nano-/micro-patterned diamond-like carbon(DLC) films
| Project/Area Number |
21760561
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural/Functional materials
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 新機能材料 / ダイヤモンドライクカーボン(DLC) |
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| Research Abstract |
The aim of this project is to develop the surface modification technique, which improve the hemocompatibility and tissue compatibility of vascular implant surface. Specifically, we designed the highly controlled new drug eluting coating by the combination of drug carrier polymer and micron-patterned diamond-like carbon(DLC) films. The main results of this project is mentioned as below, that is, 1) DLC and fluorine incorporated DLC(F-DLC) showed well compatibility with endothelial cells, then the results indicate that the DLC and F-DLC acting as platform of cells adhesion, 2) micron-patterned DLC coating well controls the drug emission from the carrier polymer and this performance is based on the piece size of micron-patterned DLC, 3) As an impregnating drug, basic fibroblast glows factor(bFGF) specifically improves the endothelial cells growth rate comparing with smooth muscle cells.
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[Journal Article] Design for improved adhesion of fluorine-incorporated hydrogenated amorphous carbon on metallic stent : three-layered structure with controlled surface free energy2011
Author(s)
Hasebe T, Murakami K, Nagashima S, Yoshimoto Y, Ihara A, Otake M, Kasai R, Kasuya S, Kitamura N, Kamijo A, Terada H, Hotta A, Takahashi K, Suzuki T
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Journal Title
Diamond and Related Materials
Volume: 20
Pages: 902-906
Peer Reviewed
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[Journal Article] 新しいデバイス開発2 :ステント・ステントグラフト2011
Author(s)
長谷部光泉, 正林康宏, 吉本幸洋, 永島壮, 笠井ルミ子, 粕谷秀輔, 北村範子, 稲岡努, 寺田一志, 谷下一夫, 鈴木哲也
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Journal Title
IVR学会誌
Volume: 26巻
Pages: 267-277
Peer Reviewed
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[Presentation] Improved Adhesion of Fluorine-doped Amorphous Carbon on Metallic Stent for Cardiovascular Disease by Introducing Interlayers with Controlled Surface Free Energies2011
Author(s)
Hasebe T, Murakami K, Nagashima S, Yoshimoto Y, Ihara A, Kasai R, Kasuya S, Terada H, Kamijo A, Hotta A, Takahashi K, Suzuki T
Organizer
8th International Symposium on Atomic Level Characterizations for New Materials and Devices' 11
Place of Presentation
Seoul(Korea)
Year and Date
20110522-27
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[Presentation] Design for improved adhesion of fluorine-incorporated hydrogenated amorphous, carbon on metal stent : three-layered structure with controlled surface free energy2010
Author(s)
Hasebe T, Murakami K, Hotta A, Kamijo A, Takahashi K, Suzuki T
Organizer
21st European Conference on Diamond, Diamond-Like Materials, Carbon Nanotubes, and Nitrides(Diamond 2010)
Place of Presentation
Kempinski Hotel Corvinus(Budapest, Hungary)
Year and Date
2010-11-07
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[Presentation] Recent advances in plasma-modified diamond-like carbon coatings for blood-contacting medical devices2010
Author(s)
Hasebe T, Kamijo A, Nagashima S, Yoshimoto Y, Ueda Y, Kitamura N, Morita H, Tanaka M, Hotta A, Terada H, Takahashi K, Suzuki T
Organizer
The European Materials Research Society(E-MRS) Spring Meeting 2010
Place of Presentation
Congress Center(Strasbourg, France)
Year and Date
2010-06-08
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[Presentation] Diamond-like carbon films for blood-contacting medical devices : Plasma-modified biomimetic surface2009
Author(s)
Hasebe T, Kamijo A, Nagashima S, Yoshimoto Y, Ueda Y, Kitamura N, Morita H, Tanaka M, Hotta A, Terada H, Takahashi K, Suzuki T
Organizer
7th International Symposium on Atomic Level Characterizations for New Materials and Devices' 09
Place of Presentation
Maui(Hawaii, USA)
Year and Date
20091206-11
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[Presentation] 脳血管内治療用デバイスに対する抗血栓性コーティングの試み:生体細胞膜模倣構造を持つMPCコーティング2009
Author(s)
長谷部光泉, 北村範子, 粕谷秀輔, 笠井ルミ子, 工藤秀康, 中塚智也, 森田英夫, 堀田篤, 上條亜紀, 鈴木哲也, 高橋孝喜, 寺田一志
Organizer
第25回NPO法人日本脳神経血管内治療学会総会
Place of Presentation
富山(日本)
Year and Date
20090919-21
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[Presentation] DLC医療分野における応用最前線:心臓血管用デバイスへの応用研究2009
Author(s)
長谷部光泉, 柏木洋介, 上田芳人, 吉本幸洋, 永島壮, 北村範子, 森田英夫, 上條亜紀, 堀田敦, 寺田一志, 高橋孝喜, 鈴木哲也
Organizer
第120回表面技術協会講演大会
Place of Presentation
千葉(日本)
Year and Date
20090917-18
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[Presentation] Challenges in prevention and treatment of late stent thrombosis : Fluorine incorporated diamond-like carbon nano-coatings2009
Author(s)
Hasebe T, Yoshimoto Y, Ishikawa O, Nagashima S, Ueda Y, Kitamura N, Kasuya S, Terada H, Tanaka M, Suzuki T, Kamijo A, Takahashi K
Organizer
17th Asian Pacific Congress of Cardiology
Place of Presentation
Kyoto(Japan)
Year and Date
20090520-23
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