2010 Fiscal Year Final Research Report
Control of drug release from biodegradable microcapsules and development of self-degradable microcapsules based on membrane technology
| Project/Area Number |
21760605
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
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| Research Institution | The University of Tokyo (2010)
Kogakuin University (2009) |
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Principal Investigator |
AKAMATSU Kazuki The University of Tokyo, 工学部, 助教 (50451795)
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| Project Period (FY) |
2009 – 2010
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| Keywords | マイクロカプセル / ミクロスフィア / 膜乳化 / SPG膜 / キトサン / 酵素 / 生分解性 / ドラッグデリバリーシステム |
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| Research Abstract |
Microcapsules were prepared with alginate or chitosan, which are biocompatible polymers, by using the membrane emulsification technique. The detailed study on preparation condition enabled us to control the average diameter, monodispersity and the hollow structure of the microcapsules. Furthermore, a novel type of self-degradable microcapsules were successfully developed and demonstrated by encapsulating the enzymes that can decompose the shell polymers of the microcapsules.
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