2010 Fiscal Year Final Research Report

Analysis of the effects of cell growth and cell death regulation on tumor development using tumor mice models

Research Project

Project/Area Number	21770001
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Genetics/Genome dynamics
Research Institution	The University of Tokyo
Principal Investigator	SUZUKI Toru The University of Tokyo, 医科学研究所, 助教 (50334280)
Project Period (FY)	2009 – 2010
Keywords	発癌モデルマウス / 細胞死 / Tob / DNA損傷
Research Abstract	Transgenic mice in which constitutively active Ras is specifically expressing in the liver (RasV12-liver mice) develop hepatocellular carcinoma (HCC). We found that the Ras-transgenic mice much more frequently develop HCC in the absence of Tob protein. Furthermore, the size of the tumors was obviously larger in the absence of Tob protein. These data suggest that Tob is responsible for suppressing HCC development and proliferation. We also examined the difference of gene expression between RasV12-liver mice and RasV12-liver mice lacking Tob. We observed the expression change in several genes involved in cell growth and death regulation. The expression change of those genes was similarly detected in more than ten mice samples, indicating that those genes are critically responsible for HCC development.

(4 results)