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2010 Fiscal Year Final Research Report

Functional analysis of Shu complex, a new mediator of Rad51 protein in recombination

Research Project

  • PDF
Project/Area Number 21770005
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Genetics/Genome dynamics
Research InstitutionOsaka University

Principal Investigator

SASANUMA Hiroyuki  Osaka University, 蛋白質研究所, 特任研究員 (00531691)

Project Period (FY) 2009 – 2010
Keywords分子遺伝 / Rad51 / Dmc1 / 減数分裂
Research Abstract

Homologous recombination is essential mechanism to repair DNA damage, such as double strand breaks. In this grant period, I found that Shu complex assists the role of Rad51 protein, which plays a central role in homologous recombination. Based on research proposal, I also successfully determined the crystal structure of Shu complex, thereby could clarified the structural relationship between Rad51 and Shu protein complex.

  • Research Products

    (14 results)

All 2011 2010 2009 2008 2007

All Journal Article (6 results) Presentation (8 results)

  • [Journal Article] Rec8 Guides Canonical Spoll Distribution along Yeast Meiotic Chromosomes.2009

    • Author(s)
      Kugou, K., Fukuda, T., Yamada, S., Ito, M., Sasanuma, H., Mori, S., Katou, Y., Itoh, T., Matsumoto, K., Shibata, T., et al.
    • Journal Title

      Mol Biol Cell 345

      Pages: 1939-4586

  • [Journal Article] タイトル『減数分裂期特異的DNA二重鎖切断機構』2009

    • Author(s)
      笹沼博之、太田邦史
    • Journal Title

      染色体サイクル(蛋白質核酸酵素・特集号)

      Pages: 459-465

  • [Journal Article] Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination.2008

    • Author(s)
      Sasanuma, H., Hirota, K., Fukuda, T., Kakusho, N., Kugou, K., Kawasaki, Y., Shibata, T., Masai, H., Ohta, K.
    • Journal Title

      Genes Dev 22

      Pages: 398-410

  • [Journal Article] Targeted induction of meiotic double-strand breaks reveals chromosomal domain-dependent regulation of Spo11 and interactions among potential sites of meiotic recombination.2008

    • Author(s)
      Fukuda, T., Kugou, K., Sasanuma, H., Shibata, T., Ohta, K.
    • Journal Title

      Nucleic Acids Res 36

      Pages: 984-997

  • [Journal Article] Meiotic association between Spoll regulated by Rec102, Rec104 and Rec114.2007

    • Author(s)
      Shibata, T., Nicolas, A., Ohta, K.
    • Journal Title

      Nucleic Acids Res, 35

      Pages: 1119-1133

  • [Journal Article] Mrell mediates gene regulation in yeast spore development.2007

    • Author(s)
      Kugou, K., Sasanuma, H., Matsumoto, K., Shirahige, K., Ohta, K.
    • Journal Title

      Genes Genet Syst 82

      Pages: 21-33

  • [Presentation] Roles of histone modification enzymes, Set1 and Dot1, and the PAF transcription elongation complex during meiosis2011

    • Author(s)
      Miki Shinohara, Hiroyuki Sasanuma, Mohamad Bani, Akira Shinohara
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      20111100
  • [Presentation] PCSS complex facilitates the loading of Rad51 recombinase onto meiotic chromosomes2010

    • Author(s)
      Hiroyuki Sasanuma, Maki Tawaramoto, Miki Shinohara, Akira Shinohara
    • Organizer
      Epigenome Network, Development and Reprogramming of Germ Cells
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      20101100
  • [Presentation] PCSS complex facilitates the loading of Rad51 recombinase onto meiotic chromosomes2010

    • Author(s)
      Hiroyuki Sasanuma, Maki Tawaramoto, Miki Shinohara, Akira Shinohara
    • Organizer
      3R symposium
    • Place of Presentation
      Toyama
    • Year and Date
      20101000
  • [Presentation] Rad51蛋白質の活性を制御する二つの因子PCSS複合体とSrs2蛋白質の解析2010

    • Author(s)
      笹沼博之、俵元麻貴、篠原美紀、篠原彰
    • Organizer
      核ダイナミクス研究会
    • Place of Presentation
      静岡
    • Year and Date
      20100500
  • [Presentation] Shu complex promotes the assembly of Rad51 on meiotic chromosomes2009

    • Author(s)
      Hiroyuki Sasanuma, Maki Tawaramoto, Miki Shinohara, Akira Shinohara
    • Organizer
      IUBMB
    • Place of Presentation
      Shunghai, China
    • Year and Date
      20090800
  • [Presentation] 減数分裂期組換えに関与するShu蛋白質の機能解析2009

    • Author(s)
      笹沼博之、俵元麻貴、篠原美紀、篠原彰
    • Place of Presentation
      静岡
    • Year and Date
      20090500
  • [Presentation] Shu complex promotes the assembly of Rad51 on meiotic chromosomes2008

    • Author(s)
      Hiroyuki Sasanuma, Miki Shinohara, Akira Shinohara
    • Place of Presentation
      Shizuoka, Japan
    • Year and Date
      20081000
  • [Presentation] 減数分裂期におけるShu複合体の機能解析2008

    • Author(s)
      笹沼博之、三田理恵、俵元麻貴、篠原美紀、篠原彰
    • Organizer
      酵母遺伝学フォーラム
    • Place of Presentation
      北海道
    • Year and Date
      20080900

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Published: 2012-02-13   Modified: 2016-04-21  

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