2010 Fiscal Year Final Research Report
Study of anaphase initiation mechanism using monaphase.
| Project/Area Number |
21770011
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Japanese Foundation For Cancer Research |
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Principal Investigator |
SHINDO Norihisa Japanese Foundation For Cancer Research, 癌研究所実験病理部, 研究員 (00512253)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 染色体 / セパレース / 染色体分離 / コヒーシン / 同期性 / バイオセンサー |
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| Research Abstract |
Sensor for separase activity was improved and it became sensitive enough to monitor separase activity during the metaphase to anaphase transition. I found that separase was tightly repressed much of metaphase and it was activated just prior to the onset of anaphase. As monaphase cells were synchronous, the cells were useful for biochemical analysis. Using these cells for biochemical assay, the mechanism of the tight regulation was revealed.
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Research Products
(8 results)
